6-Bromo-3-fluoro-N,N-bis(4-methoxybenzyl)-4-methylpyridin-2-amine CAS 2803281-45-8
| CAS No. | 2803281-45-8 |
| Molecular Formula | C22H22BrFN2O2 |
| Molecular Weight | 445.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Bromo-3-fluoro-N,N-bis(4-methoxybenzyl)-4-methylpyridin-2-amine.
6-Bromo-3-fluoro-N,N-bis(4-methoxybenzyl)-4-methylpyridin-2-amine (CAS 2803281-45-8), molecular formula C22H22BrFN2O2 and molecular weight 445.32 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, 6-Bromo-3-fluoro-N,N-bis(4-methoxybenzyl)-4-methylpyridin-2-amine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 445.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H22BrFN2O2 |
| Molecular Weight | 445.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 3,5-Dichloro-N-[3-cyano-4-(4-methylbenzenesulfonyl)phenyl]benzamide (CAS 320421-33-8)
- 2-Iodo-3-Oxo-4-aza-5α-androst-17 β-carboxylic Acid (CAS 140700-63-6)
- 3,4-Dichloro-N-(3-cyano-4-(o-tolylsulfonyl)phenyl)benzamide (CAS 320421-34-9)
- tert-Butyl (trans-4-(((5-iodopyridin-2-yl)(methyl)amino)methyl)cyclohexyl)carbamate (CAS 1313366-19-6)
- 3-Ethyl-1H-pyrazole-4-carbonitrile (CAS 1501205-06-6)
- 2-([1,1'-Biphenyl]-4-yl)propan-1-ol (CAS 6725-53-7)
- 6-chloro-5-methyl-1-tetrahydropyran-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole (CAS 2374152-83-5)
- 16-(Benzyloxy)-16-oxohexadecanoic acid (CAS 146004-98-0)
- 6-Fluoro-2-(furan-2-yl)benzo[d]thiazole (CAS 461044-05-3)
- Dimethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate (CAS 174685-34-8)
- 2-Chloro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (CAS 1889401-37-9)
- Hexane-1,6-diaminium iodide (CAS 20208-23-5)
- 4-Bromo-N-butyl-5-ethoxy-2-nitroaniline (CAS 1280786-89-1)
- D-Tyr1-Tirzepatide (CAS CATO-CPTD788928)
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