7-Bromo-2,4-dichloro-8-fluoro-6-(trifluoromethoxy)quinazoline CAS 2803281-81-2
| CAS No. | 2803281-81-2 |
| Molecular Formula | C9HBrCl2F4N2O |
| Molecular Weight | 379.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 7-Bromo-2,4-dichloro-8-fluoro-6-(trifluoromethoxy)quinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
7-Bromo-2,4-dichloro-8-fluoro-6-(trifluoromethoxy)quinazoline (CAS 2803281-81-2) is a high-purity analytical reference standard with the molecular formula C9HBrCl2F4N2O and a molecular weight of 379.92 g/mol.
The molecular framework of 7-Bromo-2,4-dichloro-8-fluoro-6-(trifluoromethoxy)quinazoline (C9HBrCl2F4N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9HBrCl2F4N2O |
| Molecular Weight | 379.92 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
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Recommended Standards
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- 4,5-Diiodophthalonitrile (CAS 175883-98-4)
- Cinchocaine EP Impurity A (CAS 87864-14-0)
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- 4-Bromo-2-chloro-3-iodo-1-(methoxymethoxy)benzene (CAS 2221812-31-1)
- (Z)-3-(benzylamino)-2-(2,2-dimethylpropanoyl)-2-propenenitrile (CAS 1024622-53-4)
- 1-[2'-(Benzyloxy)[1,1'-biphenyl]-3-yl]ethanone (CAS 893736-74-8)
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- Benzaldehyde, 2-hydroxy-3-(phenylmethoxy)- (CAS 86734-59-0)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
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