2-Mercaptopurine CAS 28128-19-0
| CAS No. | 28128-19-0 |
| Molecular Formula | C5H4N4S |
| Molecular Weight | 152.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Mercaptopurine.
2-Mercaptopurine (CAS 28128-19-0) is a high-purity analytical reference standard with the molecular formula C5H4N4S and a molecular weight of 152.18 g/mol.
The molecular framework of 2-Mercaptopurine (C5H4N4S) is characterized by a nitrile group, sulfur-containing functionality. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4N4S |
| Molecular Weight | 152.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1965 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Mercaptopurine Standards
- Mercaptopurine Impurity 2 (CAS 4897-31-8)
- 6-Methyl mercaptopurine-D3 (CAS 33312-93-5)
- Mercaptopurine Monohydrate EP Impurity B (CAS 73-24-5)
- 6-Mercaptopurine-2'-deoxyriboside, 98% (CAS 2239-64-7)
- 6-Mercaptopurine-9-β-D-ribofuranoside (CAS 574-25-4)
- 6-Mercaptopurine- (CAS 207729-57-5)
- MERCAPTOPURINE MONOHYDRATE, 6- (CAS 84-39-9)
- 6-Mercaptopurine Hydrochloride-13C,15N2 (CAS CATO-C3D-25905)
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