Estetrol Impurity 8 CAS 28200-88-6
| CAS No. | 28200-88-6 |
| Molecular Formula | C26H30O4 |
| Molecular Weight | 406.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Estetrol Impurity 8 (CAS 28200-88-6, C26H30O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Estetrol Impurity 8 (C26H30O4) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Estetrol Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H30O4 |
| Molecular Weight | 406.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥98% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
Related Estetrol Standards
- Estetrol Impurity 9 (CAS 3088028-01-4)
- Estetrol Impurity 1 (CAS CATO-C4X-32501)
- Estetrol Impurity 2 (CAS CATO-C4X-32502)
- Estetrol Impurity 3 (CAS CATO-C4X-32503)
- Estetrol Impurity 10 (CAS 3088028-02-5)
- Estetrol 17-Acetate (CAS 690996-23-7)
- Estetrol Impurity 4 (CAS CATO-C4X-32504)
- Estetrol Impurity 5 (CAS CATO-C4X-32505)
Recommended Standards
- Pentoxyverine Impurity 2 (CAS CATO-C4X-22702)
- 6-(2H-Benzo[e][1,3]oxazin-3(4H)-yl)-N2-(3-(trimethoxysilyl)propyl)-1,3,5-triazine-2,4-diamine (CAS CATO-CIM-105737)
- Pravastatin EP Impurity D (CAS 85956-22-5)
- tert-Butyl ((S)-2-(((benzyloxy)carbonyl)amino)-3-((R)-tetrahydro-2H-pyran-3-yl)propyl)(methyl)carbamate (CAS 1093869-20-5)
- Perospirone Impurity 8 (CAS 105981-34-8)
- Melphalan EP Impurity E (CAS CATO-C4X-198822)
- Vilazodone impurity 18 (CAS CATO-C4X-135518)
- 2-Bromo-3-chloromethyl-4-(trifluoromethyl)pyridine (CAS 1227578-14-4)
- trans-1-Benzyl-4-methyl-piperidin-3-ol (CAS 58878-95-8)
- 4,6-dimethylmorpholine-2-carboxylic acid hydrochloride (CAS 1955539-87-3)
- Isopropyl 2-amino-4-(4-ethylphenyl)thiophene-3-carboxylate (CAS 351157-96-5)
- 1-Ethyl-6-methylquinazolin-4(1H)-one (CAS 1379685-35-4)
- 2-Amino-2-(5-methoxy(2-pyridyl))acetic acid (CAS 1499621-79-2)
- Semaglutide impurity 39 (CAS CATO-C4X-222639)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com