7-Bromo-2,4,8-trichloro-6-(trifluoromethyl)quinazoline CAS 2823478-91-5
| CAS No. | 2823478-91-5 |
| Molecular Formula | C9HBrCl3F3N2 |
| Molecular Weight | 380.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-Bromo-2,4,8-trichloro-6-(trifluoromethyl)quinazoline.
7-Bromo-2,4,8-trichloro-6-(trifluoromethyl)quinazoline (CAS 2823478-91-5) is a high-purity analytical reference standard with the molecular formula C9HBrCl3F3N2 and a molecular weight of 380.38 g/mol.
The molecular framework of 7-Bromo-2,4,8-trichloro-6-(trifluoromethyl)quinazoline (C9HBrCl3F3N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9HBrCl3F3N2 |
| Molecular Weight | 380.38 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 2 |
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