2-(4-Ethoxybenzylidene)malononitrile CAS 2826-27-9
| CAS No. | 2826-27-9 |
| Molecular Formula | C12H10N2O |
| Molecular Weight | 198.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(4-Ethoxybenzylidene)malononitrile (CAS 2826-27-9) is a high-purity analytical reference standard with the molecular formula C12H10N2O and a molecular weight of 198.22 g/mol.
The molecular framework of 2-(4-Ethoxybenzylidene)malononitrile (C12H10N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10N2O |
| Molecular Weight | 198.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Ethoxybenzylidene Standards
- 2-(2-Ethoxybenzylidene)malononitrile (CAS 2826-31-5)
- N-(4-Ethoxybenzylidene)-1H-pyrrol-1-amine (CAS 397848-64-5)
- N-(3-Ethoxybenzylidene)-4H-1,2,4-triazol-4-amine (CAS 328262-60-8)
- N-(4-Ethoxybenzylidene)-1H-1,2,4-triazol-5-amine (CAS 322413-06-9)
- (E)-2-(4-Ethoxybenzylidene)hydrazine-1-carbothioamide (CAS 1548686-57-2)
- (Z)-5-(4-Ethoxybenzylidene)thiazolidine-2,4-dione (CAS 1099596-25-4)
- (E)-4-((4-Ethoxybenzylidene)amino)benzonitrile (CAS 24742-30-1)
- N'-(2-Ethoxybenzylidene)furan-2-carbohydrazide (CAS 292180-80-4)
Recommended Standards
- 2-(4-Ethoxy-1H-pyrazol-1-yl)-2-methylpropanoic acid (CAS 2270911-24-3)
- 2-(4-Formylphenyl)phenol (CAS 400744-38-9)
- 2-(4-(Pyrimidin-2-yl)phenyl)acetaldehyde (CAS 545423-76-5)
- 2-(4-Hydroxyphenyl)benzaldehyde (CAS 400747-55-9)
- (4-Phenoxyphenyl)(piperidin-1-yl)methanethione (CAS 959235-74-6)
- 1-(5-Chloro-2-methoxyphenyl)-2-methylpropan-2-amine (CAS 1251334-57-2)
- 3-Methoxy-1-(p-tolyl)-1H-pyrazole-5-carboxylic acid (CAS 1780386-04-0)
- 2-((1-Benzylpiperidin-4-yl)oxy)ethan-1-ol (CAS 40256-25-5)
- 6-Methoxy-2-methyl-1,2,3,4-tetrahydroquinoline (CAS 42835-96-1)
- N-(3-Amino-2-methylphenyl)-2-(4-methylphenoxy)-acetamide (CAS 1016529-45-5)
- 3-Methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-5-one (CAS 221880-28-0)
- 3-Methyloxetan-2-one (CAS 1823-54-7)
- 2-amino-N-(6-chloro-3,4-dihydro-2H-1-benzothiopyran-4-yl)pentanamide hydrochloride (CAS 1423024-29-6)
- Pancreatic Polypeptide (31-36), amide, human (CAS 74012-13-8)
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