6-Chloro-2-methyl-3H-imidazo[4,5-b]pyridine CAS 28279-50-7
| CAS No. | 28279-50-7 |
| Molecular Formula | C7H6ClN3 |
| Molecular Weight | 167.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 6-Chloro-2-methyl-3H-imidazo[4,5-b]pyridine (CAS 28279-50-7), a certified reference material (molecular formula C7H6ClN3, MW 167.60 g/mol) for analytical method development and quality control.
The molecular framework of 6-Chloro-2-methyl-3H-imidazo[4,5-b]pyridine (C7H6ClN3) is characterized by a nitrile group, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Chloro-2-methyl-3H-imidazo[4,5-b]pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6ClN3 |
| Molecular Weight | 167.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 4-Chloro-1H-pyrrolo[2,3-b]pyridin-3-amine (CAS 1000340-38-4)
- 6-Chloro-1H-pyrrolo[2,3-b]pyridin-4-amine (CAS 1000340-80-6)
- 5-Chloro-1H-pyrrolo[3,2-b]pyridin-7-amine (CAS 1000577-90-1)
- 5-Chloro-1H-indazol-6-amine (CAS 100960-35-8)
- 3-chloro-6-methyl-[1,2,4]triazolo[4,3-a]pyridine (CAS 1020036-37-6)
- 7-Chloro-1H-benzo[d]imidazol-5-amine (CAS 10597-54-3)
- 6-Chloro-1H-benzo[d]imidazol-4-amine (CAS 10597-55-4)
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Recommended Standards
- 6-Chloro-1-methyl-1H-imidazo[4,5-c]pyridine (CAS 7205-46-1)
- 6-Chloro-2-methyl-3H-imidazo[4,5-c]pyridine (CAS 7205-42-7)
- 6-Chloro-1-methyl-1H-benzo[d][1,2,3]triazole (CAS 25299-33-6)
- 6-Chloro-2-methylpyrazolo[1,5-a]pyrazine (CAS 2468028-18-2)
- Ethyl 2-bromo-3-oxo-3-[4-(trifluoromethoxy)phenyl]propanoate (CAS 887267-61-0)
- 4-Methylbiphenyl-3-ylboronic acid (CAS 1438810-09-3)
- N-(4-Cyano-3-methyl-1,2-oxazol-5-yl)-4-methylbenzamide (CAS 478043-90-2)
- (E,E)-1,1'-((Propane-1,3-diylbis(azanediyl))bis(propane-3,1-diyl))bis(2,3-dimethylguanidine) (CAS 927019-63-4)
- 4-Chloro-2-(2,4-dichlorophenyl)-5-(4-oxopiperidin-1-yl)pyridazin-3(2H)-one (CAS 338413-79-9)
- Fmoc-Pen(Acm)-OH (CAS 201531-76-2)
- 3,5-Dimethylisonicotinonitrile (CAS 7584-08-9)
- 2-(1-(2-Fluorophenyl)ethyl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (CAS 1443292-38-3)
- tert-Butyl N-{[1-(aminomethyl)-3-fluorocyclobutyl]methyl}carbamate (CAS 1638764-14-3)
- Semaglutide impurity 104(Fmoc-D-His-Aib) (CAS 2171211-18-8)
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