Methyl 2-(difluoromethylene)tetrahydro-1H-pyrrolizine-7a(5H)-carboxylate CAS 2856019-40-2
| CAS No. | 2856019-40-2 |
| Molecular Formula | C10H13F2NO2 |
| Molecular Weight | 217.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Methyl 2-(difluoromethylene)tetrahydro-1H-pyrrolizine-7a(5H)-carboxylate (CAS 2856019-40-2), a certified reference material (molecular formula C10H13F2NO2, MW 217.21 g/mol) for analytical method development and quality control.
The molecular framework of Methyl 2-(difluoromethylene)tetrahydro-1H-pyrrolizine-7a(5H)-carboxylate (C10H13F2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl 2-(difluoromethylene)tetrahydro-1H-pyrrolizine-7a(5H)-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H13F2NO2 |
| Molecular Weight | 217.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 4-(Difluoromethylene)piperidine-1-sulfonamide (CAS 2821083-71-8)
- 1-Benzyl-3-(difluoromethylene)piperidine (CAS 1356342-63-6)
- Poly(difluoromethylene), α-fluoro-ω-(2-iodoethyl)- (CAS 71215-70-8)
- (2-(Difluoromethylene)-6-methylenetetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol (CAS 2856022-95-0)
- Poly(difluoromethylene), .alpha.-fluoro-.omega.-[2-(sulfooxy)ethyl]- (CAS 65530-77-0)
- (2-(Difluoromethylene)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol (CAS 2848566-61-8)
- (R)-(2-(Difluoromethylene)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol (CAS 2820537-08-2)
- [(8S)-6-(difluoromethylene)-2,3,5,7-tetrahydro-1H-pyrrolizin-8-yl]methanol (CAS 2820537-07-1)
Recommended Standards
- 6-(Trifluoromethyl)indoline-2-thione (CAS 73425-12-4)
- Methyl 2-cyano-2-(3,3-difluorocyclohexyl)acetate (CAS 2791314-44-6)
- 5-(Trifluoromethyl)benzo[b]thiophen-2-amine (CAS 793634-52-3)
- N,N-Dibenzyl 4-Fluoro Aniline (CAS 39769-09-0)
- 2-(4-Cyclopropylphenyl)cyclopropanamine (CAS 1518733-68-0)
- 2-Amino-3-bromo-5-(trifluoromethyl)benzamide (CAS 1807101-18-3)
- (1R,2S)-2-Amino-4-methylenecyclopentane-1-carboxylic acid (CAS 198022-65-0)
- Ethyl 2-[4-(2,4-dimethoxyphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetate (CAS 861206-37-3)
- (4-Ethyl-6-(ethyl(methyl)amino)pyridin-3-yl)boronic acid (CAS 848360-84-9)
- 6-Bromo-2,4-dichloro-3-fluoroquinoline (CAS 2074702-97-7)
- (3S,4S)-3,4-Difluoropyrrolidine (CAS 863396-80-9)
- 3-(4-chlorophenyl)-6-methyl-3H-[1,2,3,4]tetraazolo[1,5-a]pyridin-4-ium tetrafluoroborate (CAS 287490-92-0)
- 2-Benzyl-2,8-diazaspiro[4.5]decan-3-one (CAS 1027844-65-0)
- Semaglutide impurity 23 (CAS CATO-C4X-222623)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com