1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethanone CAS 286017-71-8

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethanone.

1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethanone (CAS 286017-71-8), molecular formula C9H12ClF3O and molecular weight 228.64 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethanone (C9H12ClF3O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 1-(4-chloro-3-methyl-phenyl)-2,2,2-trifluoro-ethanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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