Oxcarbazepine EP Impurity F CAS 28721-08-6
| CAS No. | 28721-08-6 |
| Molecular Formula | C16H12ClNO2 |
| Molecular Weight | 285.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Oxcarbazepine EP Impurity F.
Oxcarbazepine EP Impurity F (CAS 28721-08-6) is a certified pharmaceutical impurity reference standard with the molecular formula C16H12ClNO2 and a molecular weight of 285.72 g/mol.
Structurally, Oxcarbazepine EP Impurity F (C16H12ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 285.72 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Oxcarbazepine EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12ClNO2 |
| Molecular Weight | 285.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Oxcarbazepine Standards
- Oxcarbazepine Impurity 12 (CAS 537693-30-4)
- Oxcarbazepine EP Impurity K (CAS 1346601-76-0)
- Oxcarbazepine EP Impurity L（Mixture of Tautomers） (CAS CATO-C4X-116416)
- Oxcarbazepine Impurity 22 (CAS 2642430-30-4)
- Oxcarbazepine Impurity 40 (CAS 186694-45-1)
- Oxcarbazepine Impurity 35 (CAS 98253-74-8)
- Oxcarbazepine Impurity 25 (CAS 104839-39-6)
- Oxcarbazepine EP Impurity B (CAS 28721-09-7)
Recommended Standards
- Baclofen Impurity 66 (CAS CATO-C4X-101266)
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- 1019-50-7 2-amino-5-chloro-1,4-Benzenedisulfonamide (CAS 1019-50-7)
- LCZ-696 Impurity 9 calcium salt (CAS 3081732-57-9)
- Tizanidine Nitroso Impurity 15 (CAS CATO-C4X-144515)
- Agomelatine Impurity 46 (CAS 1607465-50-8)
- ((3-Iodo-2-methylpropoxy)methyl)benzene (CAS 77397-06-9)
- (1R,7AS)-3-oxohexahydro-1H-pyrrolizine-1-carbonitrile (CAS 176040-34-9)
- 3-Bromo-5-chloro-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine (CAS 1211397-08-8)
- Oryzanol A (Cycloartenyl Ferulate) (CAS 21238-33-5)
- (R)-5-(1-Amino-3-hydroxypropan-2-yl)-2-methoxyphenolhydrochloride (CAS 2007921-03-9)
- 5-Iodo-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 97% (CAS 1644664-25-4)
- Semaglutide Impurity 139 (CAS CATO-C4X-2226139)
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