Clopidogrel Thienopyridine Impurity CAS 28783-41-7
| CAS No. | 28783-41-7 |
| Molecular Formula | C7H9NS |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Clopidogrel Thienopyridine Impurity is closely related to a nitrile group, sulfur-containing functionality, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Clopidogrel Thienopyridine Impurity (CAS 28783-41-7, C7H9NSHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clopidogrel Thienopyridine Impurity (C7H9NSHCl) contains a nitrile group, sulfur-containing functionality, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 175.67 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H9NS HCl |
| Molecular Weight | 175.67 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Clopidogrel Standards
- Clopidogrel Impurity 74 (CAS 1008008-56-7)
- Clopidogrel Impurity 82 (CAS 1015247-87-6)
- rac-Clopidogrel EP Impurity A HCl (CAS 1015247-88-7)
- rac Clopidogrel [(tert-Butylcarbonyl)oxy]methyl ester (CAS 1043913-82-1)
- 2-Oxo Clopidogrel (Mixture of Diastereomers) (CAS 109904-27-0)
- Clopidogrel Impurity 42 (CAS 109904-36-1)
- cis-Clopidogrel glutathione disulfide, mixture of diastereomers (CAS 1118605-95-0)
- Clopidogrel Impurity 48 (CAS 111954-31-5)
Recommended Standards
- Lifitegrast Impurity 144 (CAS CATO-C4X-2409144)
- Pranoprofen Impurity 41 (CAS CATO-C4X-181141)
- Urapidil impurity 101 (CAS CATO-C4X-1924101)
- 1-(5-(tert-Butylthio)-4-methylpyridin-2-yl)indoline (CAS 1355181-40-6)
- Aureofungin A (CAS 63278-45-5)
- 1-[(4-bromophenyl)methyl]cyclopropan-1-amine hydrochloride (CAS 29812-99-5)
- Tert-butyl 3-(3-aminophenyl)pyrrolidine-1-carboxylate (CAS 885270-24-6)
- 2-(Difluoromethyl)-4-iodo-3-methoxypyridine-5-carboxamide (CAS 1807094-43-4)
- Perfluorooctyltriethoxysilane (CAS 96305-13-4)
- Semaglutide Impurity 133 (CAS CATO-C4X-2226133)
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