4-(4-(Trifluoromethyl)phenoxy)piperidine hydrochloride CAS 287952-09-4
| CAS No. | 287952-09-4 |
| Molecular Formula | C12H14F3NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(4-(Trifluoromethyl)phenoxy)piperidine hydrochloride (CAS 287952-09-4), molecular formula C12H14F3NOHCl and molecular weight 281.70 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 4-(4-(Trifluoromethyl)phenoxy)piperidine hydrochloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 281.70 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(4-(Trifluoromethyl)phenoxy)piperidine hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H14F3NO HCl |
| Molecular Weight | 281.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 3-(4-(Trifluoromethyl)phenyl)pyrrolidin-3-ol hydrochloride (CAS 1000198-74-2)
- 3-(4-(Trifluoromethyl)phenyl)pyrrolidine (CAS 1000198-76-4)
- (2-Methyl-4-(trifluoromethyl)thiazol-5-yl)methanol (CAS 1000339-72-9)
- methyl 3-((4-(trifluoromethyl)piperidin-1-yl)methyl)benzoate (CAS 1000339-86-5)
- methyl 4-(2-(4-(trifluoromethyl)piperidin-1-yl)ethoxy)benzoate (CAS 1000339-87-6)
- 2-(4-(trifluoromethyl)piperidin-1-yl)thiazole-5-carbaldehyde (CAS 1000339-88-7)
- 3-(2-(4-(trifluoromethyl)piperidin-1-yl)ethyl)benzaldehyde (CAS 1000339-89-8)
- 4-(2-(4-(trifluoromethyl)piperidin-1-yl)acetyl)-1H-pyrrole-2-carbaldehyde (CAS 1000339-90-1)
Recommended Standards
- 5-Ethylpyrimidine-2-carboxylic acid (CAS 1554782-53-4)
- N-(4-benzhydrylpiperazine-1-carbonothioyl)-2,6-difluorobenzamide (CAS 1023494-95-2)
- 5-(2-(4-Methylcyclohex-3-en-1-yl)propyl)dihydrofuran-2(3H)-one (CAS 93840-87-0)
- 2,2'-Selenodiacetic acid (CAS 6228-62-2)
- 1-(1-Butyl-2-methyl-1H-pyrrol-3-yl)ethanone (CAS 112722-71-1)
- N-(3-Fluoro-4-methylphenyl)-2-((5-(pyridin-4-yl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 578722-52-8)
- 2-[5-Fluoro-2-(toluene-4-sulfonylimino)-2H-pyridin-1-yl]-acetamide (CAS 1123163-32-5)
- 6-Bromospiro[chromane-2,1'-cyclobutan]-4-one (CAS 934555-03-0)
- 7-Thia-2-aza-spiro[3.5]nonane 7,7-dioxide oxalate(2:1) (CAS 1501856-47-8)
- [γ-Glu]15 Semaglutide (CAS CATO-C4X-222690)
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