(E)-3-Bromo-2-methylacrylonitrile CAS 28976-77-4
| CAS No. | 28976-77-4 |
| Molecular Formula | C4H4BrN |
| Molecular Weight | 145.99 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 145.99 g/mol gives (E)-3-Bromo-2-methylacrylonitrile distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(E)-3-Bromo-2-methylacrylonitrile (CAS 28976-77-4), molecular formula C4H4BrN and molecular weight 145.99 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrile group, bromine substitution, (E)-3-Bromo-2-methylacrylonitrile is typically white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 145.99 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-3-Bromo-2-methylacrylonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H4BrN |
| Molecular Weight | 145.99 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related E Standards
- 3-Bromo-2-methylacrylonitrile (CAS 150163-13-6)
- 2-Bromo-1H-pyrrole (CAS 38480-28-3)
- 3-Bromo-1H-pyrrole (CAS 87630-40-8)
- 3-Bromo-3-butenenitrile (CAS 22468-43-5)
- 4-Bromo-2-butenenitrile (CAS 42879-03-8)
- 1-Bromo-2-methylpropane-d9 (CAS 1080497-35-3)
- 2-Bromo-2-methylpropane-d9 (CAS 42310-83-8)
- 3-Bromo-1,2,4-triazol-4-ide (CAS 57704-26-4)
Recommended Standards
- (E)-2-Bromobut-2-enenitrile (CAS 24325-95-9)
- (2E)-4-Bromobut-2-enenitrile, E (CAS 37590-23-1)
- 2-(Bromomethyl)acrylonitrile (CAS 17200-53-2)
- Triethyl borate (CAS 150-46-9)
- 2-Chloro-4-methyl-N-(thiophen-3-ylmethyl)aniline (CAS 1039901-30-8)
- (5-Methyl-3-phenyl-4-isoxazolyl)methanol (CAS 18718-79-1)
- 4-[(Propane-2-sulfonyl)methyl]aniline (CAS 635702-61-3)
- Perfluoro-n-octanesulfonic acid-13C4 (CAS 960354-19-2)
- 2-(1-Tetrazolyl)benzamide (CAS 449758-24-1)
- 6-Bromo-2-isopropyl-3,4-dihydroisoquinolin-1(2H)-one (CAS 879887-39-5)
- Formaldehyde, polymer with 6-phenyl-1,3,5-triazine-2,4-diamine and 1,3,5-triazine-2,4,6-triamine (CAS 25035-72-7)
- 2-[2-(1-aminopropyl)phenoxy]-N,N-dimethylacetamide (CAS 954277-53-3)
- 2-((4-Amino-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-ethoxyphenyl)acetamide (CAS 586992-91-8)
- Semaglutide impurity 261 (CAS CATO-C4X-2226261)
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