Ethyl 3-oxo-2,4-diphenylbutanoate CAS 2901-29-3
| CAS No. | 2901-29-3 |
| Molecular Formula | C18H18O3 |
| Molecular Weight | 282.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Ethyl 3-oxo-2,4-diphenylbutanoate (CAS 2901-29-3), a pharmacopoeial impurity reference standard (molecular formula C18H18O3, MW 282.33 g/mol) used for the identification and quantification of trace impurities in APIs.
Ethyl 3-oxo-2,4-diphenylbutanoate (C18H18O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18O3 |
| Molecular Weight | 282.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Recommended Standards
- Ethyl 3,4,5-triethoxybenzoate (CAS 31374-71-7)
- Ethyl 3-oxo-4,4-diphenylbutanoate (CAS 25022-02-0)
- Ethyl 3-(3-phenylpropanoyl)benzoate (CAS 898764-12-0)
- Methyl (4aR,5R,8aR)-8a-methyl-6-oxooctahydro-2H-spiro[naphthalene-1,2'-[1,3]dioxolane]-5-carboxylate (CAS 287401-07-4)
- Milnacipran Impurity 40 (CAS 1100753-09-0)
- Cetirizine Impurity 46 HCl (CAS CATO-C4X-108346)
- Melitracen Impurity 7 (CAS 42332-94-5)
- 1-(4-Fluoropyridin-3-yl)cyclopropane-1-carboxylic acid (CAS 1427011-71-9)
- (S)-2-Amino-1-[(S)-3-(benzyl-methyl-amino)-piperidin-1-yl]-propan-1-one (CAS 1401668-01-6)
- (4-Cyclopropoxy-2-(methylthio)pyridin-3-yl)methanamine (CAS 1243387-74-7)
- 4-Fluoro-3-hydroxy-2-nitropyridine (CAS 1609165-98-1)
- 4,5-Dibromo-3-chlorotoluene (CAS 953794-53-1)
- 1-(2-Fluorophenyl)-2-methylpropan-2-amine hydrochloride (CAS 1957-24-0)
- Neuropeptide Y, human (CAS 98264-90-5)
Why CATO?
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