5-Methyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridinesulfonamide CAS 290815-30-4
| CAS No. | 290815-30-4 |
| Molecular Formula | C22H18ClN5O4S |
| Molecular Weight | 483.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Methyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridinesulfonamide (CAS 290815-30-4) is a high-purity analytical reference standard with the molecular formula C22H18ClN5O4S and a molecular weight of 483.93 g/mol.
Structurally, 5-Methyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-2-pyridinesulfonamide (C22H18ClN5O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 483.93 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H18ClN5O4S |
| Molecular Weight | 483.93 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Recommended Standards
- 3-Amino-N-(5-chloro-2-methoxyphenyl)-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 939888-82-1)
- (2Z)-3-[4-(4-Chlorophenyl)-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,5-trien-3-yl]-2-[3-(trifluoromethyl)phenyl]prop-2-enenitrile (CAS 383147-93-1)
- Clopidogrel Impurity 987 (CAS CATO-C4X-1029987)
- Avanafil Impurity 54 (CAS 1706458-94-7)
- (2-Methoxyphenyl)(2-(piperidin-1-ylmethyl)phenyl)methanone (CAS 898751-74-1)
- H-Arg-Tyr-OH (CAS 74863-12-0)
- 4-Bromo-2-(difluoromethyl)-5-methoxypyridine (CAS 1805315-01-8)
- Benzyl N-[2-(4-bromophenyl)propan-2-yl]carbamate (CAS 578729-08-5)
- Bis(naphthalen-1-ylmethyl)amine (CAS 5798-49-2)
- Itraconazole Impurity 31 (CAS CATO-C4X-149731)
- cis-2-Hydroxycyclohexanecarboxamide (CAS 73045-98-4)
- (S)-3-Cyclohexyl-4-methoxy-4-oxobutanoic acid (CAS 213270-44-1)
- 2-Methyl-6-(3-methyl-piperidin-3-yl)-pyrimidin-4-ol dihydrochloride (CAS 1361112-82-4)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
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