1-((2-Chlorophenyl)sulfonyl)-4',5'-dimethylspiro[indoline-3,2'-[1,3]dioxolan]-2-one CAS 294853-28-4
| CAS No. | 294853-28-4 |
| Molecular Formula | C18H16ClNO5S |
| Molecular Weight | 393.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 393.84 g/mol gives 1-((2-Chlorophenyl)sulfonyl)-4',5'-dimethylspiro[indoline-3,2'-[1,3]dioxolan]-2-one distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1-((2-Chlorophenyl)sulfonyl)-4',5'-dimethylspiro[indoline-3,2'-[1,3]dioxolan]-2-one (CAS 294853-28-4), molecular formula C18H16ClNO5S and molecular weight 393.84 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-((2-Chlorophenyl)sulfonyl)-4',5'-dimethylspiro[indoline-3,2'-[1,3]dioxolan]-2-one (C18H16ClNO5S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-((2-Chlorophenyl)sulfonyl)-4',5'-dimethylspiro[indoline-3,2'-[1,3]dioxolan]-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16ClNO5S |
| Molecular Weight | 393.84 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
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Recommended Standards
- (R)-2-((tert-butoxycarbonyl)amino)-3-(3'-chloro-4'-fluoro-[1,1'-biphenyl]-4-yl)propanoic acid (CAS 845530-07-6)
- Besifloxacin (CAS 141388-76-3)
- Besifloxacin Impurity 1 (CAS CATO-C4X-10041)
- Besifloxacin Impurity 2 (CAS CATO-C4X-10042)
- 4-(3-Formylphenyl)phenol (CAS 283147-95-5)
- 1-(3-Fluorophenyl)cyclopentan-1-ol (CAS 204850-89-5)
- N,N-dimethylpyrrolidine-3-sulfonamide hydrochloride (CAS 1825309-05-4)
- 2-Bromo-N-(2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl)acetamide (CAS 136669-49-3)
- Tert-butyl 3-(((tert-butoxycarbonyl)amino)methyl)-4-(methoxyimino)pyrrolidine-1-carboxylate (CAS 175463-81-7)
- Methyl 3-nitro-4-(pyrrolidin-1-yl)benzoate (CAS 91567-80-5)
- 2-{[(2,6-dichlorophenyl)methyl]sulfanyl}-4-hydroxy-6-phenylpyrimidine-5-carbonitrile (CAS 478261-70-0)
- 4-Amino-2-chloro-5-(difluoromethyl)pyridin-3-ol (CAS 1804723-10-1)
- 5-Isopropyl-3-methylisothiazol-4-amine (CAS 2567560-95-4)
- Semaglutide impurity 107 (CAS CATO-C4X-2226107)
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