Methylphenidate hydrochloride CAS 298-59-9
| CAS No. | 298-59-9 |
| Molecular Formula | C14H19NO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methylphenidate hydrochloride.
Methylphenidate hydrochloride (CAS 298-59-9), molecular formula C14H19NO2HCl and molecular weight 269.77 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Methylphenidate hydrochloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 269.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methylphenidate hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H19NO2 HCl |
| Molecular Weight | 269.77 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Methylphenidate Standards
- Methylphenidate-d9 hydrochloride solution (CAS 1219804-02-0)
- Methylphenidate-d9 (CAS 1219908-85-6)
- Methylphenidate D10 (CAS 1246912-03-7)
- Methylphenidate (CAS 20748-11-2)
- Methylphenidate EP Impurity B (CAS 20748-12-3)
- Methylphenidate Hydrochloride Erythro Isomer (CAS 29419-96-3)
- 【精神药品品种目录第一类，管控禁售品】Methylphenidate Hydrochloride Erythro Isomer Solution (0.5 mL) (CAS 29419-97-4)
- Methylphenidate Hydrochloride Erythro Isomer (CAS 40431-63-8)
Recommended Standards
- Ivabradine Impurity 76 (CAS 55171-70-5)
- 3-Chloro-N-({3-[(1E)-1-(methoxyimino)ethyl]-4,5-dihydro-1,2-oxazol-5-yl}methyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 344276-92-2)
- Methyl 3-chloro-3-phenylcyclobutane-1-carboxylate (CAS 30493-91-5)
- 5-(1-(4-Bromophenyl)ethoxy)-4-chloro-2-ethylpyridazin-3(2H)-one (CAS 88093-53-2)
- Tri-O-acetyl-D-[1- (CAS 478529-35-0)
- 1-(Phenylsulfonyl)-1H-indol-6-amine (CAS 478404-02-3)
- 2-Chloro-5-(2,5-dioxo-pyrrolidin-1-yl)-benzoic acid (CAS 313480-55-6)
- 6-Chloro-7-methyl-[1,2,4]triazolo[4,3-b]pyridazine (CAS 58826-39-4)
- 2,2',7,7'-Tetraethynyl-9,9'-spirobifluorene (CAS 1103763-99-0)
- Semaglutide Impurity 165 (CAS CATO-C4X-2226165)
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