2-Chloropyrimidine-4,6-dicarbonitrile CAS 29872-58-0
| CAS No. | 29872-58-0 |
| Molecular Formula | C6HClN4 |
| Molecular Weight | 164.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Chloropyrimidine-4,6-dicarbonitrile (C6HClN4) is characterized by a nitrile group, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-Chloropyrimidine-4,6-dicarbonitrile (CAS 29872-58-0) is a high-purity analytical reference standard with the molecular formula C6HClN4 and a molecular weight of 164.55 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6HClN4 |
| Molecular Weight | 164.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloropyrimidine Standards
- 5-chloropyrimidine-2-carboxylic acid (CAS 38275-61-5)
- 6-chloropyrimidine-4-carboxylic acid (CAS 37131-91-2)
- 6-Chloropyrimidine-2,4,5-triamine (CAS 1194-78-1)
- 5-Chloropyrimidine-2,4,6-triamine (CAS 24867-23-0)
- 2-Chloropyrimidine-4-carboxylic Acid (CAS 149849-92-3)
- 2-Chloropyrimidine-5-carboxylic Acid (CAS 374068-01-6)
- 4-Chloropyrimidine-5-carboxylic acid (CAS 933686-33-0)
- 5-Chloropyrimidine-4-carboxylic Acid (CAS 64224-65-3)
Recommended Standards
- Voriconazole Impurity 90 (CAS CATO-C4X-136690)
- 3-Chloropyrazine-2,5-dicarbonitrile (CAS 918410-50-1)
- 5-Chloro-2,4-difluorophenol (CAS 2268-01-1)
- 2,2-Difluoroethanesulfonyl Chloride (CAS 1033906-60-3)
- 4-(Isocyanomethyl)pyridine (CAS 58644-56-7)
- 4-Chloro-5-ethoxy-2-nitroaniline (CAS 579474-32-1)
- 1-(2-(1,3-Dimethyl-5-phenoxy-1H-pyrazol-4-yl)ethyl)-3-phenylurea (CAS 477711-47-0)
- 2-CHloro-n-(4-fluorophenyl)-n-(4-methoxybenzyl)acetamide (CAS 1176501-35-1)
- Sodium 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (CAS 1255098-70-4)
- 2-Phenyl-N-((2-(pyridin-3-yl)benzo[d]oxazol-5-yl)carbamothioyl)acetamide (CAS 590395-09-8)
- N-(4-Formylpyrimidin-2-yl)acetamide (CAS 180869-44-7)
- ((1R,3r)-3-aminocyclobutyl)(spiro[3.3]Heptan-2-yl)methanone (CAS 2277115-65-6)
- 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-aminopyridine-5-boronic acid, pinacol ester 2-aminopyridine-5-boronic acid pinacol ester 6-aminopyridine-3-boronic acid pinacol ester 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine 2-aminopyridine-5-boronic acid,pinacol ester 827614-64-2 (CAS 827614-64-2)
- C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 127869-51-6)
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