2,5-Difluorobenzoic acid CAS 2991-28-8
| CAS No. | 2991-28-8 |
| Molecular Formula | C7H4F2O2 |
| Molecular Weight | 158.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,5-Difluorobenzoic acid (C7H4F2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
2,5-Difluorobenzoic acid (CAS 2991-28-8) is a high-purity analytical reference standard with the molecular formula C7H4F2O2 and a molecular weight of 158.10 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4F2O2 |
| Molecular Weight | 158.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Difluorobenzoic Standards
- 3,5-Difluorobenzoic acid (CAS 455-40-3)
- 3,4-Difluorobenzoic acid (CAS 455-86-7)
- 2,6-Difluorobenzoic Acid (CAS 385-00-2)
- 2,5-Difluorobenzoic-d3 Acid (CAS 1219798-63-6)
- 3,4-Difluorobenzoic-d3 Acid (CAS 1219798-70-5)
- 2,6-Difluorobenzoic-d3 Acid (CAS 1219804-21-3)
- 2,4-Difluorobenzoic-d3 Acid (CAS 1219804-63-3)
- 3,5-Difluorobenzoic-d3 Acid (CAS 934397-71-4)
Recommended Standards
- 2,5-Difluoro-4-hydroxybenzaldehyde (CAS 918523-99-6)
- 2,6-Difluoro-4-hydroxybenzaldehyde (CAS 532967-21-8)
- 2,4-Difluoro-3-hydroxybenzaldehyde (CAS 192927-69-8)
- 2-Hydroxy-4,5-difluorobenzaldehyde (CAS 199287-52-0)
- 2-((Furan-3-carbonyl)oxy)acetic acid (CAS 62149-68-2)
- [S(R)]-N-[(R)-[6-(Diphenylphosphino)benzo[d][1,3]dioxol-5-yl]-1-naphthalenylmethyl]-N,2-dimethyl-2-propanesulfinamide (CAS 2565792-42-7)
- Methyl 2-amino-3-chloro-5-fluorobenzoate (CAS 1184351-57-2)
- 6-Fluoro-4-(trifluoromethyl)quinolin-2(1H)-one (CAS 328956-08-7)
- 5-(Thiophen-2-yl)oxazole (CAS 70380-70-0)
- Pyrrole-2-acetic Acid (CAS 79673-53-3)
- 1-[(3-Fluorophenyl)methyl]-4-nitro-1h-pyrazole (CAS 1007477-02-2)
- 4-Chloro-2-(cyclopropylmethoxy)pyridine (CAS 1346707-02-5)
- Ethyl 5-isobutylisoxazole-3-carboxylate (CAS 110578-27-3)
- Palmitoyl Tripeptide-8 TFA salt (CAS 936544-53-5)
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