5-((2-Chloro-5-nitrophenyl)methylene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one CAS 299904-13-5
| CAS No. | 299904-13-5 |
| Molecular Formula | C12H9ClN2O3S2 |
| Molecular Weight | 328.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-((2-Chloro-5-nitrophenyl)methylene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one.
5-((2-Chloro-5-nitrophenyl)methylene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one (CAS 299904-13-5) is a high-purity analytical reference standard with the molecular formula C12H9ClN2O3S2 and a molecular weight of 328.79 g/mol.
5-((2-Chloro-5-nitrophenyl)methylene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one (C12H9ClN2O3S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-((2-Chloro-5-nitrophenyl)methylene)-3-ethyl-2-thioxo-1,3-thiazolidin-4-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9ClN2O3S2 |
| Molecular Weight | 328.79 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Chloro Standards
- 1'-Benzyl-6-chloro-3H-spiro[furo[3,4-c]pyridine-1,4'-piperidin]-3-one (CAS 1017598-71-8)
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- Ethyl 4-(2-chloro-6-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 134074-31-0)
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Recommended Standards
- 3-((2-Chlorophenethyl)amino)-1-phenylpyrrolidine-2,5-dione (CAS 494853-47-3)
- Ethyl 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate (CAS 861151-22-6)
- Ethyl 7-(4-chlorophenyl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxylate (CAS 338406-13-6)
- 2'-(4-Chlorophenyl)-3,4-dihydro-1H-spiro[naphthalene-2,5'-[1,3]dioxan]-1-one (CAS 338418-41-0)
- 5-Amino-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (CAS 5373-68-2)
- 1-(4-(((1-(tert-Butyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)amino)phenyl)butan-1-one (CAS 1091670-54-0)
- N-(4-fluorobenzyl)-4-(4-methoxybenzoyl)-1H-pyrrole-2-carboxamide (CAS 478259-67-5)
- 5-(3,4-Dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 333761-27-6)
- (2-Hydroxy-phenyl)-propynoic acid ethyl ester (CAS 160559-13-7)
- 3-(5-(2-Chlorophenyl)furan-2-yl)-N-(3-methoxyphenyl)acrylamide (CAS 853348-25-1)
- Ethyl 3-hydroxy-9,9-dimethyl-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carboxylate (CAS 870562-16-6)
- tert-Butyl (1-oxo-1-(phenylamino)propan-2-yl)carbamate (CAS 126787-11-9)
- 1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-yn-2-one (CAS 89965-74-2)
- Semaglutide impurity 71 (CAS CATO-C4X-222671)
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