2-Amino-5-fluoro-4-methylpyridine CAS 301222-66-2
| CAS No. | 301222-66-2 |
| Molecular Formula | C6H7FN2 |
| Molecular Weight | 126.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Amino-5-fluoro-4-methylpyridine (CAS 301222-66-2), molecular formula C6H7FN2 and molecular weight 126.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Amino-5-fluoro-4-methylpyridine (C6H7FN2) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 2-Amino-5-fluoro-4-methylpyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H7FN2 |
| Molecular Weight | 126.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 2-Amino-5-fluoro-6-methylpyridine (CAS 110919-71-6)
- 4-Amino-5-fluoro-2-methylpyridine (CAS 1211590-22-5)
- 3-Amino-2-fluoro-4-methylpyridine (CAS 173435-32-0)
- 5-Amino-2-fluoro-3-picoline (CAS 186593-48-6)
- 5-Amino-2-fluoro-4-methylpyridine 6-fluoro-4-methyl-pyridin-3-ylamine 5-amino-2-fluoro-4 methylpyridine 954236-33-0 (CAS 954236-33-0)
- 3-Amino-6-methyl-1,2,4-triazin-5(4H)-one (CAS 1004-04-2)
- 5-Amino-1H-1,2,3-triazole-4-carboximidamide (CAS 16968-07-3)
- 4-amino-1H-imidazole-2-carboxamide (CAS 50283-75-5)
Recommended Standards
- 2-(Aminomethyl)-5-fluoropyridine (CAS 561297-96-9)
- 2-Fluoro-3-methylphenol (CAS 77772-72-6)
- 2-(Aminomethyl)-3-fluoropyridine (CAS 312904-51-1)
- 2-Fluoro-4,6-dimethylpyrimidine (CAS 38953-33-2)
- N-(3-methoxybenzyl)cyclopropanamine hydrochloride (CAS 1050419-13-0)
- Ethyl 3-[3,5-bis(trifluoromEthyl)phenyl]-3-oxopropanoate (CAS 175278-02-1)
- [1,1'-Biphenyl]-2,4'-diyldimethanol (CAS 187344-44-1)
- 2-m-Tolyl-morpholine hydrochloride (CAS 62008-56-4)
- Dapoxetine Impurity 99 (CAS CATO-C4X-143999)
- Dapagliflozin C2 Epimer (CAS 2133407-75-5)
- α-D-Glucosamine pentaacetate (CAS 7784-54-5)
- 4-Ethyl-3-fluorophenol (CAS 326493-65-6)
- 2-(((1-((Benzyloxy)carbonyl)pyrrolidin-3-yl)methyl)(isopropyl)amino)acetic acid (CAS 1353960-61-8)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
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