5,7-Difluoroindole CAS 301856-25-7
| CAS No. | 301856-25-7 |
| Molecular Formula | C8H5F2N |
| Molecular Weight | 153.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5,7-Difluoroindole (CAS 301856-25-7), molecular formula C8H5F2N and molecular weight 153.13 g/mol, is a CATO reference standard with documented purity and traceability.
5,7-Difluoroindole (C8H5F2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 5,7-Difluoroindole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F2N |
| Molecular Weight | 153.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoroindole Standards
- 4,5-Difluoroindole (CAS 247564-63-2)
- 4,6-Difluoroindole (CAS 199526-97-1)
- 5,6-Difluoroindole-2-carboxylic Acid (CAS 169674-35-5)
- 4,6-Difluoroindole-2-carboxylic acid (CAS 247564-66-5)
- Methyl 4,5-Difluoroindole-2-carboxylate (CAS 1339009-36-7)
- Methyl 4,6-Difluoroindole-2-carboxylate (CAS 394222-99-2)
- Ethyl 4,5-Difluoroindole-2-carboxylate (CAS 194870-66-1)
Recommended Standards
- 4-Amino-5,5-difluoropentanoic acid (CAS 78347-71-4)
- 6,7-Difluoro-1H-indole (CAS 271780-84-8)
- 4,7-Difluoro-1H-indole (CAS 247564-55-2)
- Methyl 2-amino-3,3-difluoro-2-methylpropanoate (CAS 87492-65-7)
- 2-(Benzo[d][1,3]dioxol-5-yl)isonicotinic acid (CAS 1258627-04-1)
- N-Boc-5-chloroindole-2-boronic acid, 97% (CAS 475102-12-6)
- MIL-88A(Fe) (CAS 1138446-56-6)
- (Z)-3-(((3,4-dichlorobenzyl)oxy)imino)-1-phenylindolin-2-one (CAS 341964-30-5)
- 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-5-carboxylic acid (CAS 1006340-71-1)
- 2-Cyano-N-isopropylacetamide (CAS 52573-74-7)
- tert-Butyl (S)-2-(4-nitrobenzyl)piperazine-1-carboxylate (CAS 1260604-60-1)
- N-benzyl-1-(2-chloro-8-methylquinolin-3-yl)methanamine (CAS 606095-53-8)
- 3-Carbamoylpiperazine-2-carboxylic acid (CAS 98549-53-2)
- Fragment-[3-31]-Liraglutide (CAS CATO-C4X-199232)
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