Piperazine impurity 49 CAS 3029270-07-0
| CAS No. | 3029270-07-0 |
| Molecular Formula | - |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Piperazine impurity 49 (C5H4D8N2HCl) is characterized by deuterium isotope labeling, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Piperazine impurity 49 (CAS 3029270-07-0, C5H4D8N2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4D8N2 HCl |
| Molecular Weight | 144.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Piperazine Standards
- (4-(Piperazine-1-carbonyl)phenyl)boronic acid (CAS 1003043-13-7)
- 4,4'-(Piperazine-1,4-diyl)dibenzaldehyde (CAS 10159-39-4)
- 3-(piperazine-1-carbonyl)-1,2-dihydropyridin-2-one (CAS 1016519-58-6)
- 3-(Piperazine-1-carbonyl)benzonitrile (CAS 1016684-78-8)
- Piperazine Impurity 7 (CAS 1025895-66-2)
- 2-(Piperazine-1-carbonyl)-1h-indole hydrochloride (CAS 1028800-67-0)
- Piperazine Impurity 15 (CAS 10430-90-7)
- 4-(Piperazine-1-sulfonyl)benzonitrile hydrochloride (CAS 1044761-22-9)
Recommended Standards
- Enarodustat Impurity 30 (CAS CATO-C4X-322830)
- Melatonin Impurity 25 (CAS 573983-93-4)
- Febuxostat Impurity 89 (CAS CATO-C4X-116289)
- N-(3-methoxypropyl)-3-methylcyclohexan-1-amine (CAS 55611-91-1)
- Erlotinib D4 (CAS 1130852-41-3)
- 3-Hydroxy-N,4-dimethylbenzamide (CAS 348165-50-4)
- N,N'-(Butane-1,4-diyl)diacrylamide (CAS 10405-38-6)
- (4-(2-Hydroxypropan-2-yl)pyridin-2-yl)boronic acid (CAS 1310385-00-2)
- Ethyl pyrrolo[1,2-a]pyrimidine-7-carboxylate (CAS 61900-67-2)
- D-[Thr]5-Semaglutide (CAS CATO-C4X-2226245)
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