2-[4-(difluoromethoxy)phenyl]quinoline-4-carboxylic acid CAS 302936-16-9
| CAS No. | 302936-16-9 |
| Molecular Formula | C17H11F2NO3 |
| Molecular Weight | 315.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-[4-(difluoromethoxy)phenyl]quinoline-4-carboxylic acid (CAS 302936-16-9), a certified reference material (molecular formula C17H11F2NO3, MW 315.27 g/mol) for analytical method development and quality control.
2-[4-(difluoromethoxy)phenyl]quinoline-4-carboxylic acid (C17H11F2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H11F2NO3 |
| Molecular Weight | 315.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related difluoromethoxy Standards
- N-(4-(Difluoromethoxy)phenyl)-N,2-dimethylquinazolin-4-amine (CAS 827031-16-3)
- 2-(Difluoromethoxy)-4-iodonitrobenzene (CAS 1261440-42-9)
- 4-(Difluoromethoxy)-1-iodo-2-nitrobenzene (CAS 1261453-57-9)
- 2-(Difluoromethoxy)-3-iodonitrobenzene (CAS 1261499-84-6)
- 2-(Difluoromethoxy)-5-iodonitrobenzene (CAS 1261584-39-7)
- 1-(Difluoromethoxy)-2-iodo-4-nitrobenzene (CAS 1261776-70-8)
- 2-(Difluoromethoxy)-3,4,5,6-tetrafluorobenzenesulfonyl chloride (CAS 2773501-57-6)
- 6-(Difluoromethoxy)-3-phenylbenzo[4,5]imidazo[2,1-b]thiazole (CAS 339016-08-9)
Recommended Standards
- 2,6-Diphenyltetrahydro-4H-selenopyran-4-one (CAS 67139-96-2)
- 3-[3-(Trifluoromethyl)benzamido]thiophene-2-carboxylic acid (CAS 866150-49-4)
- 2-(4-Fluorophenyl)-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)acetamide (CAS 899958-61-3)
- 4-(2,4-Difluorophenoxy)-5-methoxy-2-(pyridin-2-yl)pyrimidine (CAS 338771-61-2)
- 1-(1,7-Diazaspiro[3.5]Nonan-1-yl)ethan-1-one (CAS 1422061-77-5)
- 3-Chloro-5-fluoro-2-methoxypyridin-4-amine (CAS 2450342-96-6)
- N1,2-dimethylpropane-1,3-diamine (CAS 1251384-75-4)
- 4-Hydroxy-2-(methylthio)benzaldehyde (CAS 1243396-42-0)
- 3-((3,5-Dimethyl-1H-1,2,4-triazol-1-yl)methyl)benzoic acid (CAS 1281441-10-8)
- 2-oxo-2-(pyrrolidin-1-yl)acetohydrazide (CAS 27844-18-4)
- 2-Oxohexahydro-3,5-methanocyclopenta[b]pyrrole-6a(1H)-carboxylic acid (CAS 286456-64-2)
- 2-(Aminomethyl)-5-cyano-4-(difluoromethyl)pyridine (CAS 1805203-53-5)
- 4-Methyl-N'-(4-methyl-1,2,3-thiadiazole-5-carbonyl)benzenesulfonohydrazide (CAS 477872-09-6)
- Semaglutide impurity 40 (CAS CATO-C4X-222640)
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