(5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl acetate CAS 303148-59-6
| CAS No. | 303148-59-6 |
| Molecular Formula | C8H8ClF3N2O2 |
| Molecular Weight | 256.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl acetate (CAS 303148-59-6) is a high-purity analytical reference standard with the molecular formula C8H8ClF3N2O2 and a molecular weight of 256.61 g/mol.
(5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl acetate (C8H8ClF3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures (5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl acetate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H8ClF3N2O2 |
| Molecular Weight | 256.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-[4-chloro-5-methyl-3-(trifluoromethyl)-1h-pyrazol-1-yl]propanoic acid (CAS 1001518-84-8)
- 2-[4-chloro-5-methyl-3-(trifluoromethyl)-1h-pyrazol-1-yl]propanoic acid (CAS 1005679-11-7)
- 2-[4-chloro-3-(trifluoromethyl)-1h-pyrazol-1-yl]butanoic acid (CAS 1006333-14-7)
- 4-Chloro-6-(trifluoromethyl)quinoline-3-carbonitrile (CAS 1017788-96-3)
- 7-Chloro-6-(trifluoromethyl)quinoline-2-carbonitrile (CAS 1375604-42-4)
- 6-Chloro-7-(trifluoromethyl)quinoline-2-carbonitrile (CAS 1375604-76-4)
- Ethyl 5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 155377-06-3)
- 4-Chloro-7-(trifluoromethyl)quinoline-3-carbonitrile (CAS 157301-81-0)
Recommended Standards
- Methyl 4-chloro-1-(3,3,3-trifluoropropyl)-1H-pyrazole-3-carboxylate (CAS 1856075-94-9)
- 2-(4-Chloro-5-methyl-3-(trifluoromethyl)-1h-pyrazol-1-yl)acetohydrazide (CAS 956396-58-0)
- Ethyl 4-chloro-1-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxylate (CAS 1856043-39-4)
- 2,2-Difluorobenzo[d][1,3]dioxole-4-sulfonyl chloride (CAS 89819-42-1)
- α-Helical CRF (9-41) (CAS 99658-03-4)
- 4,6-Dimethyl-2-piperidin-4-ylpyrimidine dihydrochloride (CAS 1803600-56-7)
- 4-Bromo-3-((tetrahydrofuran-3-yl)oxy)aniline (CAS 1698250-79-1)
- (S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethan-1-amine (CAS 1071435-62-5)
- 1-(2-(1H-imidazol-1-yl)phenyl)-3-(3-chlorophenyl)urea (CAS 68008-39-9)
- 2-Amino-6-(hydroxymethyl)-8-oxo-4-(o-tolyl)-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile (CAS 876709-95-4)
- Methyl 8-Methoxyquinoline-3-carboxylate (CAS 911109-15-4)
- 5-Bromo-2,2-dimethyl-2,3-dihydro-1H-inden-1-amine (CAS 2408957-56-0)
- (8-fluoro-2-oxo-1H-quinolin-5-yl) acetate (CAS 2420455-88-3)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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