N-(4-chlorophenyl)-2,2-difluoro-2-(4-methoxyphenoxy)acetamide CAS 303150-79-0
| CAS No. | 303150-79-0 |
| Molecular Formula | C15H12ClF2NO3 |
| Molecular Weight | 327.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies N-(4-chlorophenyl)-2,2-difluoro-2-(4-methoxyphenoxy)acetamide (CAS 303150-79-0), a certified reference material (molecular formula C15H12ClF2NO3, MW 327.71 g/mol) for analytical method development and quality control.
The molecular framework of N-(4-chlorophenyl)-2,2-difluoro-2-(4-methoxyphenoxy)acetamide (C15H12ClF2NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), N-(4-chlorophenyl)-2,2-difluoro-2-(4-methoxyphenoxy)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12ClF2NO3 |
| Molecular Weight | 327.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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- 1-(4-Chlorophenyl)-3-{[4-(trifluoromethyl)phenyl]amino}propan-1-one (CAS 477334-15-9)
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Recommended Standards
- 2-((2-((4-Chloro-2-(trifluoromethyl)phenyl)amino)-2-oxoethyl)thio)acetic acid (CAS 338421-31-1)
- 1-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroquinoline-6-sulfonyl chloride (CAS 947498-97-7)
- 2-((2-Acetamido-6-chloro-9H-purin-9-yl)methoxy)ethyl acetate (CAS 120356-08-3)
- (2-Bromo-6-iodopyridin-4-yl)boronic acid (CAS 2225175-26-6)
- 2,4-Dichloro-6-methylbenzotrifluoride (CAS 1806346-92-8)
- Methyl 6-amino-4-fluoropicolinate (CAS 1446509-55-2)
- 8-CHloro-6-nitro-imidazo[1,2-a]pyridine (CAS 1936087-76-1)
- N-(3-Amino-4-chlorophenyl)-2-(3-methylphenoxy)-acetamide (CAS 953736-03-3)
- 2,2',4,5,6'-Pentabromodiphenyl Ether (CAS 446254-66-6)
- (R)-2-Amino-2-(5-chloropyridin-2-yl)ethan-1-ol (CAS 1213442-79-5)
- 3,4-Diethoxy-N-hydroxybenzimidamide (CAS 1201448-00-1)
- 5-(Chloromethyl)-1-hexyl-2-methanesulfonyl-1h-imidazole (CAS 1221341-20-3)
- 2-(9h-Carbazol-9-yl)ethan-1-amine hydrochloride (CAS 57168-24-8)
- Semaglutide impurity 63 (CAS CATO-C4X-222663)
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