5-((4-Chlorophenyl)thio)-N-methyl-1,2,3-thiadiazole-4-carboxamide CAS 303151-37-3
| CAS No. | 303151-37-3 |
| Molecular Formula | C10H8ClN3OS2 |
| Molecular Weight | 285.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-((4-Chlorophenyl)thio)-N-methyl-1,2,3-thiadiazole-4-carboxamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-((4-Chlorophenyl)thio)-N-methyl-1,2,3-thiadiazole-4-carboxamide (CAS 303151-37-3), molecular formula C10H8ClN3OS2 and molecular weight 285.77 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-((4-Chlorophenyl)thio)-N-methyl-1,2,3-thiadiazole-4-carboxamide (C10H8ClN3OS2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8ClN3OS2 |
| Molecular Weight | 285.77 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
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Recommended Standards
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- Chlorambucil EP Impurity A (CAS 27171-89-7)
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- 5-(2-Ethylpyrimidin-4-yl)-4-methylthiazol-2-amine (CAS 1217487-09-6)
- Bis(4-aminophenyl)phenylamine (CAS 4117-90-2)
- 2-Ethynyl-5-phenylpyridine (CAS 1196156-08-7)
- 1-(2-(2-Hydroxyethoxy)ethyl)-3-phenyl-2-thioxoimidazolidin-4-one (CAS 55036-71-0)
- 2-(prop-2-en-1-yloxy)propan-1-amine (CAS 1250811-11-0)
- Alogliptin impurity 83 (CAS CATO-C4X-109983)
- Mivacurium chloride Impurity 47 (CAS CATO-C4X-137547)
- N-Methyl-1-(2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-yl)methanamine dihydrochloride (CAS 2126177-02-2)
- Glucagon (1-29) (CAS 16941-32-5)
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