8-(5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]Decane CAS 303151-61-3
| CAS No. | 303151-61-3 |
| Molecular Formula | C17H15F6N3O2 |
| Molecular Weight | 407.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 8-(5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]Decane.
8-(5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]Decane (CAS 303151-61-3), molecular formula C17H15F6N3O2 and molecular weight 407.31 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 8-(5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]Decane (C17H15F6N3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 407.31 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H15F6N3O2 |
| Molecular Weight | 407.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Bis Standards
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Recommended Standards
- 4-(4-Chlorophenoxy)-2-{[(4-chlorophenyl)methyl]sulfanyl}-6-(methoxymethyl)pyrimidine (CAS 338748-07-5)
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- 4-((3,4-Dichlorobenzyl)thio)-5-ethoxy-2-phenylpyridazin-3(2H)-one (CAS 5509-76-2)
- tert-Butyl 4-hydroxy-4-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}piperidine-1-carboxylate (CAS 877399-39-8)
- (R)-Ethyl 3-aminobutanoate hydrochloride (CAS 146293-15-4)
- 3-(1,3-Oxazol-5-yl)piperidine dihydrochloride (CAS 1864062-33-8)
- 3-(Aminomethyl)-5,6-dimethylpyrazin-2-amine (CAS 113238-60-1)
- Methyl 5-cyano-2-nitro-4-(trifluoromethyl)benzoate (CAS 1805121-00-9)
- 1-(3-Fluorophenyl)-6-mercapto-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (CAS 1416342-35-2)
- (6,7-Dimethoxychroman-4-yl)methanamine (CAS 123891-64-5)
- 2-Methylbenzofuran-5-carboxylic acid (CAS 219763-06-1)
- 2-(tert-Butoxy)-4-hydroxy-N,N-dimethylbenzamide (CAS 1243367-71-6)
- 5-Bromo-N-(4-bromobenzo[d]thiazol-2-yl)thiophene-2-carboxamide (CAS 892857-21-5)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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