1,1-Bis(4-fluorophenyl)-2-phenylmethanesulfonylethan-1-ol CAS 303152-07-0
| CAS No. | 303152-07-0 |
| Molecular Formula | C21H18F2O3S |
| Molecular Weight | 388.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1,1-Bis(4-fluorophenyl)-2-phenylmethanesulfonylethan-1-ol (C21H18F2O3S) is characterized by a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
1,1-Bis(4-fluorophenyl)-2-phenylmethanesulfonylethan-1-ol (CAS 303152-07-0) is a high-purity analytical reference standard with the molecular formula C21H18F2O3S and a molecular weight of 388.43 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1,1-Bis(4-fluorophenyl)-2-phenylmethanesulfonylethan-1-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H18F2O3S |
| Molecular Weight | 388.43 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Bis Standards
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Recommended Standards
- 1-((2R,4aR,7S,8R,8aR)-8-Fluoro-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)propan-2-one (CAS 852234-96-9)
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- 1-(((1-(Tert-butoxycarbonyl)piperidin-4-yl)methoxy)carbonyl)-4-fluoropiperidine-4-carboxylic acid (CAS 2306275-51-2)
- 2-(4-Benzoylphenyl)-N-((dimethylamino)methylene)-2-(4-fluorophenyl)acetamide (CAS 860609-44-5)
- 2-Propenoic acid, 1,1'-(1,6-hexanediyl) ester, polymer with 2,5-furandione and 4-methoxyphenol (CAS 73597-24-7)
- (S)-2-Amino-2-(3-(methylthio)phenyl)ethanol (CAS 1213614-81-3)
- 1-Allyl-3-(4,6-difluorobenzo[d]thiazol-2-yl)urea (CAS 1206998-57-3)
- 6-Hydroxystigmasta-4，22-dien-3-one (CAS 36450-01-8)
- (E)-6-benzyl-2,6-diazaspiro[3.4]octan-8-one O-methyl oxime (CAS 219680-61-2)
- 4-Bromo-2-(4,4-difluoropiperidin-1-yl)nitrobenzene 1774894-40-4 (CAS 1774894-40-4)
- (S)-2-((1-((Benzyloxy)carbonyl)piperidin-3-yl)(cyclopropyl)amino)acetic acid (CAS 1354000-59-1)
- 1-methoxy-3-phenylpropan-2-amine (CAS 72296-90-3)
- Rivaroxaban EP Impurity G (CAS 446292-08-6)
- Peptide Impurity 27 (CAS 1350456-68-6)
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