4-(Hydroxymethyl)-1-phenylpyrazolidin-3-one CAS 30346-45-3
| CAS No. | 30346-45-3 |
| Molecular Formula | C10H12N2O2 |
| Molecular Weight | 192.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(Hydroxymethyl)-1-phenylpyrazolidin-3-one (CAS 30346-45-3), molecular formula C10H12N2O2 and molecular weight 192.21 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Hydroxymethyl)-1-phenylpyrazolidin-3-one (C10H12N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12N2O2 |
| Molecular Weight | 192.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Nitrogen Atoms | 2 |
Related Hydroxymethyl Standards
- 1-(HYDROXYMETHYL)CYCLOPROPYL BENZOATE (CAS 1245931-97-8)
- 4-(hydroxymethyl)-4-(pyridin-2-yl)pyrrolidin-2-one (CAS 1864051-60-4)
- 5-(Hydroxymethyl)-1,3-dimethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (CAS 345657-96-7)
- 7-(Hydroxymethyl)-3-methyl-7,8-dihydrocinnolin-5(6H)-one (CAS 924898-04-4)
- Methyl 4-(hydroxymethyl)cubane-1-carboxylate (CAS 60462-19-3)
- 1-(4-(Hydroxymethyl)phenyl)pentan-1-one (CAS 30611-26-8)
- 5-(Hydroxymethyl)-1H-indazole-3-carboxylic acid (CAS 1061265-00-6)
- 3-(Hydroxymethyl)-1h-indazole-5-carboxylic acid (CAS 1082041-77-7)
Recommended Standards
- 4-(Cyclopropylmethoxy)benzoic acid (CAS 355391-05-8)
- 4-(Isobutyryl)benzoic acid (CAS 32018-30-7)
- 4-(Cyclopropylmethoxy)-3-hydroxybenzaldehyde (CAS 943749-55-1)
- 4-(N,N-Dimethylcarbamimidoyl)benzoic acid (CAS 244257-76-9)
- 2-(2-Cyano-6-(difluoromethyl)-4-hydroxypyridin-3-yl)acetic acid (CAS 1805376-35-5)
- Ethyl 8-cyclobutyl-8-oxooctanoate (CAS 898776-24-4)
- n-(3-Fluorophenyl)-1-methylpiperidin-4-amine (CAS 36796-55-1)
- 2-(4-Pyridyl)-2-propylamine (CAS 566155-76-8)
- Methyl 4-(5-amino-1,3,4-thiadiazol-2-yl)butanoate (CAS 227958-77-2)
- N-(1H-Benzo[d][1,2,3]triazol-1-yl)propionamide (CAS 501917-74-4)
- N-(4H-Chromeno[4,3-d]thiazol-2-yl)-4-ethoxybenzamide (CAS 681158-44-1)
- N-(4-chloro-3-nitrobenzyl)-2,4-difluoroaniline (CAS 306731-94-2)
- Quinoline-2-carboxylic acid hydrochloride (CAS 89047-45-0)
- [His]1+12-Semaglutide (CAS CATO-C4X-2226178)
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