(3E)-3-[2-(3,5-Dichlorophenyl)hydrazin-1-ylidene]-1-{[3-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-1H-indol-2-one CAS 303984-88-5
| CAS No. | 303984-88-5 |
| Molecular Formula | C22H14Cl2F3N3O |
| Molecular Weight | 464.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (3E)-3-[2-(3,5-Dichlorophenyl)hydrazin-1-ylidene]-1-{[3-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-1H-indol-2-one.
(3E)-3-[2-(3,5-Dichlorophenyl)hydrazin-1-ylidene]-1-{[3-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-1H-indol-2-one (CAS 303984-88-5), molecular formula C22H14Cl2F3N3O and molecular weight 464.27 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (3E)-3-[2-(3,5-Dichlorophenyl)hydrazin-1-ylidene]-1-{[3-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-1H-indol-2-one (C22H14Cl2F3N3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures (3E)-3-[2-(3,5-Dichlorophenyl)hydrazin-1-ylidene]-1-{[3-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-1H-indol-2-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H14Cl2F3N3O |
| Molecular Weight | 464.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related E Standards
- (2Z)-3-[4-(2,4-Dichlorophenyl)-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,5-trien-3-yl]-2-(3-methylphenyl)prop-2-enenitrile (CAS 478041-78-0)
- 3-[(2,6-Dichlorophenyl)methyl]-1-(2-{[(4-fluorophenyl)methyl]sulfanyl}-2-methylpropyl)-2-methyl-1,4-dihydropyridin-4-one (CAS 478246-02-5)
- (2,6-Dichlorophenyl)formonitrile Oxide (CAS 2904-62-3)
- N-(3,4-dichlorophenyl)-2-((2,4,5-trichlorophenyl)sulfonyl)hydrazine-1-carboxamide (CAS 706772-78-3)
- 3-((2,6-Dichlorophenyl)thio)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 1-oxide (CAS 477762-70-2)
- N-(4-(2,4-dichlorophenyl)thiazol-2-yl)-2-((3-(trifluoromethyl)phenyl)thio)acetamide (CAS 338957-97-4)
- 6-[({3-[(2,4-dichlorophenyl)methoxy]phenyl}formohydrazido)carbonyl]cyclohex-3-ene-1-carboxylic acid (CAS 478039-16-6)
- 1-(3-(3,4-Dichlorophenyl)imidazo[1,2-a]pyridin-8-yl)-3-(3-(trifluoromethyl)phenyl)urea (CAS 338415-26-2)
Recommended Standards
- ((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl 4-(bromomethyl)benzoate (CAS 97143-48-1)
- (Z)-({1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}methylidene)[(4-chlorophenyl)methoxy]amine (CAS 338410-01-8)
- Cloransulam-Methyl Impurity 9 (CAS CATO-C4X-31709)
- 5,6-Dimethoxy-8-nitroquinoline (CAS 5333-02-8)
- 2-Amino-7-methoxy-1H-indole-3,5-dicarboxamide (CAS 2639848-89-6)
- Ethyl 2-amino-2-(4-(methylsulfonyl)phenyl)propanoate (CAS 1179736-16-3)
- 2-(AMINOMETHYL)THIAZOLE-5-CARBOXYLIC ACID (CAS 933742-24-6)
- (2-(Dimethyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)silyl)phenyl)methanol (CAS 947515-75-5)
- 3-((4-Methoxybenzyl)thio)-1h-1,2,4-triazole (CAS 17357-75-4)
- 3-(2,5-Dimethoxyphenyl)-N-(naphthalen-1-yl)-2-(2H-1,2,3,4-tetrazol-5-yl)propanamide (CAS 483995-61-5)
- 1-(4-Methoxyphenyl)isoquinolin-3(2H)-one (CAS 61561-66-8)
- 2,3,7,8-Tetrahydroindolizine-5(6H)-thione (CAS 325956-88-5)
- Methyl 5-formyl-2-methoxybenzoate (CAS 78515-16-9)
- Prolactin-Releasing Peptide (12-31), rat (CAS 222988-10-5)
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