(3E)-3-[2-(2-Chlorophenyl)hydrazin-1-ylidene]-1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indol-2-one CAS 303985-21-9
| CAS No. | 303985-21-9 |
| Molecular Formula | C21H14Cl3N3O |
| Molecular Weight | 430.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (3E)-3-[2-(2-Chlorophenyl)hydrazin-1-ylidene]-1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indol-2-one.
(3E)-3-[2-(2-Chlorophenyl)hydrazin-1-ylidene]-1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indol-2-one (CAS 303985-21-9) is a high-purity analytical reference standard with the molecular formula C21H14Cl3N3O and a molecular weight of 430.71 g/mol.
(3E)-3-[2-(2-Chlorophenyl)hydrazin-1-ylidene]-1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indol-2-one (C21H14Cl3N3O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H14Cl3N3O |
| Molecular Weight | 430.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related E Standards
- (3E)-3-[2-(3-Chlorophenyl)hydrazin-1-ylidene]-1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indol-2-one (CAS 303985-20-8)
- 4-(4-Chlorophenyl)-1-(6-(2,4-dichlorobenzyl)pyridazin-3-yl)-1H-pyrazol-5-amine (CAS 321385-77-7)
- (4-Chlorophenyl)(4-(((2,4-dichlorophenyl)thio)methyl)-4-hydroxypiperidin-1-yl)methanone (CAS 866143-80-8)
- N-((4-Chlorophenyl)carbamoyl)-2-(((6-nitro-4-oxoquinazolin-3(4H)-yl)methyl)amino)acetamide (CAS 76979-57-2)
- 5-(4-Chlorophenyl)-3-(4-methoxyphenyl)-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole (CAS 551921-56-3)
- 2-{[(4-chlorophenyl)methyl]sulfanyl}-5-[1-methyl-3-(trifluoromethyl)-1H-thieno[2,3-c]pyrazol-5-yl]-1,3,4-oxadiazole (CAS 478080-23-8)
- 3-[(4-Chlorophenyl)methyl]-1-[(4-methylphenyl)methanesulfonyl]-3-(pyrazin-2-yl)urea (CAS 866150-91-6)
- N-[4-(2-Chlorophenyl)-1,3-thiazol-2-yl]-2-[4-(2-fluorophenyl)piperazin-1-yl]acetamide (CAS 338750-04-2)
Recommended Standards
- (2S, 4S, 8S)-α-Tocopherol (CAS 77171-97-2)
- (2S, 4S, 8R)-α-Tocopherol (CAS 79434-82-5)
- (3β,5α,6β,22R,24R)-6-Methoxy-3,5-Cycloergostan-22-ol (CAS 71473-15-9)
- (2S, 4R, 8S)-α-Tocopherol (CAS 79434-83-6)
- 20-OTES-Camptothecin (CAS 1004264-93-0)
- 2-((2-Formylbenzofuran-3-yl)thio)acetic acid (CAS 41872-96-2)
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- 1-(2-Isothiocyanatoethoxy)-2-methoxybenzene (CAS 887405-52-9)
- 4-(5-Methoxy-1H-indol-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 2306269-04-3)
- 8-Iodo-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one (CAS 147916-85-6)
- (Z)-3-Cyclopropylcarbamoyl-acrylic acid (CAS 925413-02-1)
- (R)-2-((1-(tert-Butoxycarbonyl)piperidin-3-yl)oxy)acetic acid (CAS 1354008-66-4)
- 2-(Bromomethyl)-1-ethyl-1H-imidazole hydrobromide (CAS 2138353-64-5)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
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