(1E,4E)-1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(dimethylamino)penta-1,4-dien-3-one CAS 303997-44-6
| CAS No. | 303997-44-6 |
| Molecular Formula | C13H12ClF3N2O |
| Molecular Weight | 304.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (1E,4E)-1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(dimethylamino)penta-1,4-dien-3-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(1E,4E)-1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(dimethylamino)penta-1,4-dien-3-one (CAS 303997-44-6), molecular formula C13H12ClF3N2O and molecular weight 304.70 g/mol, is a CATO reference standard with documented purity and traceability.
(1E,4E)-1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(dimethylamino)penta-1,4-dien-3-one (C13H12ClF3N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (1E,4E)-1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(dimethylamino)penta-1,4-dien-3-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12ClF3N2O |
| Molecular Weight | 304.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- 8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-one (CAS 1823184-22-0)
- 1-(4-Chlorophenyl)-2-((4-fluorophenyl)diazenyl)-3-hydroxyprop-2-en-1-one (CAS 338400-44-5)
- 4-Chloro-1-cyclohexyl-6-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1443290-42-3)
- 2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetonitrile (CAS 338979-38-7)
- Methyl 2-(5-chloro-2-hydroxyphenyl)acetate (CAS 441356-47-4)
- 2-Propenoic acid, 2-methyl-, dodecyl ester, polymer with methyl 2-methyl-2-propenoate and 2-propenoic acid, potassium salt (CAS 66090-76-4)
- Acenaphtho[1,2-d][1,3]thiazol-8-amine (CAS 7496-68-6)
- 2-Bromo-6-methylpyrazino[2,3-b]pyrazine (CAS 91225-51-3)
- 759457-29-9 (1-Methylpiperidin-4-ylidene)acetic acid DTXSID50424414 (CAS 759457-29-9)
- 4-Amino-5-[(2-pyridin-2-yl-1H-benzimidazol-1-yl)methyl]-4H-1,2,4-triazole-3-thiol (CAS 895835-38-8)
- 2-(Quinolin-2-ylthio)benzo[d]thiazole (CAS 119993-80-5)
- 4-[(E)-{[3-(trifluoromethyl)phenyl]methylidene}amino]phenyl 2,4,6-trimethylbenzene-1-sulfonate (CAS 329778-31-6)
- N-((1-Ethyl-4-methyl-1H-pyrazol-5-yl)methyl)-1-(2-fluoroethyl)-4-methyl-1H-pyrazol-3-amine hydrochloride (CAS 1856099-35-8)
- Semaglutide impurity 275 (CAS CATO-C4X-2226275)
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