Ivabradine Impurity 12 CAS 304464-97-9
| CAS No. | 304464-97-9 |
| Molecular Formula | C26H34N2O5 |
| Molecular Weight | 454.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Ivabradine Impurity 12 (CAS 304464-97-9, C26H34N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C26H34N2O5, Ivabradine Impurity 12 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 454.56 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Ivabradine Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H34N2O5 |
| Molecular Weight | 454.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
Related Ivabradine Standards
- Ivabradine Impurity 17 (CAS 304462-60-0)
- Ivabradine Impurity 33 (CAS CATO-C4X-111933)
- Ivabradine Impurity 41 (CAS CATO-C4X-111941)
- Ivabradine Impurity 47 (CAS CATO-C4X-111947)
- Ivabradine Impurity 59 (CAS 2247881-26-9)
- Ivabradine impurity 94 (CAS CATO-C4X-111994)
- Ivabradine Impurity 28 (CAS CATO-C4X-111928)
- Ivabradine - API Standards (CAS 155974-00-8)
Recommended Standards
- 198561-38-5 Carbamic acid,[(1S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-1-(hydroxymethyl)pentyl]-,9H-fluoren-9-ylmethyl ester (CAS 198561-38-5)
- Octimibate, >98% (HPLC) (CAS 89838-96-0)
- ML 349 (CAS 890819-86-0)
- Diindeno[7,1-qr:1′,7′-st][1,4,7,10,13,16]hexaoxacycloheneicosin, 5,6,8,9,11,12,14,15,17,18,23,24,25,26-tetradecahydro-, (24aR)- (CAS 879014-42-3)
- Methionine Impurity 11 (CAS 33770-86-4)
- Tunodafil Impurity 14 (CAS CATO-C4X-311014)
- Oxybuprocaine Impurity 8 (CAS CATO-C4X-12278)
- 3-((3,4-Difluorophenoxy)methyl)benzaldehyde (CAS 1443305-93-8)
- Arteminin (CAS 466639-11-2)
- 3-Cyclopropyl-1-phenyl-1h-1,2,4-triazole-5-thiol (CAS 923193-02-6)
- 5,6,7,8-Tetrahydrocyclohepta[c]pyrazol-4(1H)-one (CAS 1314139-85-9)
- D-Mannose-6-phosphate Sodium Salt (CAS 70442-25-0)
- N-Ethyl-[1,2,5]thiadiazolo[3,4-d]pyrimidin-7-amine (CAS 89712-90-3)
- Peptide 433 (CAS CATO-CPTD788433)
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