4-[(4-Boc-1-piperazinyl)methyl]aniline CAS 304897-49-2
| CAS No. | 304897-49-2 |
| Molecular Formula | C16H25N3O2 |
| Molecular Weight | 291.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-[(4-Boc-1-piperazinyl)methyl]aniline (CAS 304897-49-2), molecular formula C16H25N3O2 and molecular weight 291.39 g/mol, is a CATO reference standard with documented purity and traceability.
4-[(4-Boc-1-piperazinyl)methyl]aniline (C16H25N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H25N3O2 |
| Molecular Weight | 291.39 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
Related Boc Standards
- 5-[(4-Boc-1-piperazinyl)methyl]pyridin-2-amine (CAS 1178566-52-3)
- 2-(4-Boc-1-piperazinyl)pyrimidine-5-carbonitrile (CAS 1241898-04-3)
- 4-(4-Benzyl-1-piperazinyl)-6-chloropyrimidine (CAS 188527-14-2)
- 4-(4-Methyl-1-piperazinyl)-3-(trifluoromethyl)benzoic Acid (CAS 677704-61-9)
- 3-(1-Piperazinyl)phenylboronic Acid Pinacol Ester (CAS 871125-87-0)
- 2-(1-Piperazinyl)pyridine-4-boronic acid pinacol ester 957198-31-1 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine (CAS 957198-31-1)
- 4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)aniline (CAS 630125-91-6)
- 2-(4-Benzyl-1-piperazinyl)isonicotinic Acid (CAS 1019373-73-9)
Recommended Standards
- 4-(1-Cbz-4-piperidyl)-1-butanol (CAS 566905-88-2)
- 4-[9-Methoxy-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl]-1-butanol (CAS 910646-95-6)
- 3-Nitro-1-(4-octylphenyl)propan-1-one (CAS 899822-97-0)
- 4-Hydroxy-4-o-tolylpiperidine-1-carboxylic acid tert-butyl ester (CAS 553630-96-9)
- 2-(Azepan-1-yl)-5-bromoaniline (CAS 1016736-79-0)
- 5-ethoxypyrazine-2-carboxylic acid (CAS 1220330-11-9)
- (2S,3S)-2,3-Oxiranedicarboxylic Acid Monoethyl Ester (CAS 89886-73-7)
- 4-Cyclopropoxy-N2-methylpyridine-2,3-diamine (CAS 1243382-85-5)
- 1-(propan-2-yl)-1H-indazol-6-amine (CAS 938514-13-7)
- 4-Bromo-5-chloro-2-methoxybenzene-1-sulfonyl chloride (CAS 1208076-81-6)
- N-ethyl-3-fluoropyridin-2-amine (CAS 220714-70-5)
- 2-Phenoxyquinoxaline (CAS 52598-53-5)
- 2-{[4-(4-chlorophenyl)-5-phenyl-4h-1,2,4-triazol-3-yl]sulfanyl}acetic acid (CAS 727717-72-8)
- Semaglutide Impurity 137 (x TFA Salt) (CAS CATO-C4X-2226137)
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