4-[(2E)-3-(4-Fluorophenyl)prop-2-enoyl]phenyl 2,2-dimethylpropanoate CAS 306730-41-6
| CAS No. | 306730-41-6 |
| Molecular Formula | C20H19FO3 |
| Molecular Weight | 326.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-[(2E)-3-(4-Fluorophenyl)prop-2-enoyl]phenyl 2,2-dimethylpropanoate.
4-[(2E)-3-(4-Fluorophenyl)prop-2-enoyl]phenyl 2,2-dimethylpropanoate (CAS 306730-41-6), molecular formula C20H19FO3 and molecular weight 326.36 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-[(2E)-3-(4-Fluorophenyl)prop-2-enoyl]phenyl 2,2-dimethylpropanoate (C20H19FO3) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H19FO3 |
| Molecular Weight | 326.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related E Standards
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Recommended Standards
- 4-(Difluoromethyl)-6-(3,4-dimethylphenyl)-2-(ethylsulfonyl)pyrimidine (CAS 862661-63-0)
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- 3-(9-anthryl)-1-(4-fluorophenyl)prop-2-en-1-one (CAS 28143-81-9)
- (1-(Phenylsulfonyl)piperidine-4-carbonyl)glycine (CAS 1017421-58-7)
- Butyltin hydroxide oxide hydrate 97% (CAS 304671-74-7)
- (1-(Benzhydrylamino)-3-methylbutyl)(hydroxy)(oxo)phosphonium (CAS 65577-21-1)
- 2-(2-Bromo-4-(difluoromethyl)-5-(trifluoromethyl)pyridin-3-yl)acetonitrile (CAS 1805044-52-3)
- Methyl 3-carbamoyl-4-nitrobenzoate (CAS 76143-34-5)
- 4-Chloro-1H-indol-6-amine hydrochloride (CAS 1134724-15-4)
- 1-(4-Chloro-phenyl)-2-(1,3-dioxolan-2-yl)-ethanone (CAS 58582-69-7)
- 4-Chloro-3-methylbutanenitrile (CAS 7659-47-4)
- Ethyl 5-chloro-4-methylthiophene-2-carboxylate (CAS 74598-04-2)
- Ethyl 2-(3,5-difluoro-2-methoxyphenyl)-2-oxoacetate (CAS 1256480-13-3)
- Acetyl-Exenatide trifluoroacetate salt (CAS 305815-28-5)
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