4-[(2E)-3-(Thiophen-2-yl)prop-2-enoyl]phenyl 2,2-dimethylpropanoate CAS 306730-46-1
| CAS No. | 306730-46-1 |
| Molecular Formula | C18H18O3S |
| Molecular Weight | 314.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-[(2E)-3-(Thiophen-2-yl)prop-2-enoyl]phenyl 2,2-dimethylpropanoate (CAS 306730-46-1) is a high-purity analytical reference standard with the molecular formula C18H18O3S and a molecular weight of 314.40 g/mol.
The molecular framework of 4-[(2E)-3-(Thiophen-2-yl)prop-2-enoyl]phenyl 2,2-dimethylpropanoate (C18H18O3S) is characterized by a steroid core, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18O3S |
| Molecular Weight | 314.40 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Sulfur Atoms | 1 |
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