3-[4-Nitro-3-(trifluoromethyl)phenoxy]-N-phenylthiophene-2-carboxamide CAS 306977-61-7
| CAS No. | 306977-61-7 |
| Molecular Formula | C18H11F3N2O4S |
| Molecular Weight | 408.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-[4-Nitro-3-(trifluoromethyl)phenoxy]-N-phenylthiophene-2-carboxamide (CAS 306977-61-7), molecular formula C18H11F3N2O4S and molecular weight 408.35 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C18H11F3N2O4S, 3-[4-Nitro-3-(trifluoromethyl)phenoxy]-N-phenylthiophene-2-carboxamide contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 408.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-[4-Nitro-3-(trifluoromethyl)phenoxy]-N-phenylthiophene-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H11F3N2O4S |
| Molecular Weight | 408.35 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 3-(4-Nitrophenoxy)-N-[3-(trifluoromethyl)phenyl]thiophene-2-carboxamide (CAS 252026-89-4)
- Letermovir Impurity 49 (CAS CATO-C4X-291549)
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- 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(2-methoxybenzyl)thiourea (CAS 1024572-83-5)
- 2-Chloro-3-hydroxy-1-methylpyridin-1-ium 4-methylbenzenesulfonate (CAS 73059-19-5)
- N-METHOXY-N-METHYL-1,4-DIOXASPIRO[4.5]DECANE-8-CARBOXAMIDE (CAS 158243-48-2)
- (R)-2-((tert-butoxycarbonyl)amino)-3-(6-methylpyridin-3-yl)propanoic acid (CAS 1992860-86-2)
- 1-Methyl-3-phenylpyrazin-2(1H)-one (CAS 828267-06-7)
- (R)-1-(2-Fluoro-5-nitrophenyl)ethan-1-ol (CAS 1931921-04-8)
- methyl 6-[(methylamino)methyl]pyridine-3-carboxylate dihydrochloride (CAS 1909336-84-0)
- Methyl 1-carbamoylcyclopropanecarboxylate (CAS 6914-80-3)
- (3aR,8aR)-4,4,8,8-Tetrakis(3,5-di-tert-butylphenyl)-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine 6-oxide (CAS 2222165-61-7)
- 5-Bromo-3-isopropoxybenzofuran-2-carboxylic acid (CAS 1707581-36-9)
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