6,8-Dichloro-3-hydroxy-2-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one CAS 306978-99-4
| CAS No. | 306978-99-4 |
| Molecular Formula | C15H7Cl2F3N2O2 |
| Molecular Weight | 375.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
6,8-Dichloro-3-hydroxy-2-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one (CAS 306978-99-4), molecular formula C15H7Cl2F3N2O2 and molecular weight 375.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6,8-Dichloro-3-hydroxy-2-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one (C15H7Cl2F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 6,8-Dichloro-3-hydroxy-2-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H7Cl2F3N2O2 |
| Molecular Weight | 375.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichloro Standards
- 2,6-dichloro-4-{4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}pyridine (CAS 680215-90-1)
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- 2,4-Dichloro-5-(n-(2-(pyridin-2-yl)ethyl)sulfamoyl)benzoic acid (CAS 725710-61-2)
- 5,7-Dichloro-N-methyl-N-phenylthiazolo[4,5-d]pyrimidine-2-sulfonamide (CAS 1000573-34-1)
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- 5,7-Dichloro-N-(p-tolyl)thiazolo[4,5-d]pyrimidine-2-sulfonamide (CAS 1000576-31-7)
- 2,6-Dichloro-3-[chloro-(4-chloro-phenyl)-methyl]-4-trifluoromethyl-pyridine (CAS 1311280-36-0)
- 2,5-Dichloro-N-(4,5-dihydronaphtho[1,2-d]thiazol-2-yl)benzamide (CAS 392246-45-6)
Recommended Standards
- 2-(2H-1,3-Benzodioxol-5-yl)-3,8-dichloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 866145-84-8)
- Fenazaflor (CAS 14255-88-0)
- Tributyl(5,6-dihydro-1,4-dioxin-2-yl)stannane (CAS 131470-66-1)
- 2,2,3,3,4,4,4-Heptafluoro-N-(2-fluoro-5-(trifluoromethyl)phenyl)butanamide (CAS 1024127-50-1)
- 1-[1-(propan-2-yl)-1h-pyrazol-3-yl]propan-2-one (CAS 1342027-45-5)
- 3-iodo-5-methyl-4H-1,2,4-triazole (CAS 23579-76-2)
- ICa (CAS 3374-88-7)
- (R)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXAMIDE (CAS 89013-95-6)
- 5-(2-Bromoethyl)-1-methyl-1h-pyrazole (CAS 1340091-69-1)
- 2-(Methoxymethyl)piperidine hydrochloride (CAS 688809-98-5)
- 1030102-15-8 1-[4-(2-Methoxyphenyl)piperazin-1-yl]isoquinoline-4-carboxylic acid MFCD14281719 (CAS 1030102-15-8)
- Scutebarbatine B (CAS 905929-95-5)
- (2Z)-2-[(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene]-2,3-dihydro-1H-inden-1-one (CAS 497060-08-9)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
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