2-chloro-4-(1H-1,2,3,4-tetrazol-1-yl)benzoic acid CAS 309720-72-7
| CAS No. | 309720-72-7 |
| Molecular Formula | C8H5ClN4O2 |
| Molecular Weight | 224.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-chloro-4-(1H-1,2,3,4-tetrazol-1-yl)benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-chloro-4-(1H-1,2,3,4-tetrazol-1-yl)benzoic acid (CAS 309720-72-7) is a high-purity analytical reference standard with the molecular formula C8H5ClN4O2 and a molecular weight of 224.60 g/mol.
The molecular framework of 2-chloro-4-(1H-1,2,3,4-tetrazol-1-yl)benzoic acid (C8H5ClN4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H5ClN4O2 |
| Molecular Weight | 224.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
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- 1-(2-Chloro-4-nitrophenyl)-1H-1,2,4-triazole (CAS 856452-73-8)
- 3-CHloro-6-hydroxy-[1,5]naphthyridine-4-carboxylic acid (CAS 2065250-61-3)
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- 3-(chloromethyl)cyclohexan-1-one (CAS 57719-96-7)
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- (S)-1-(3-Chloropyridin-4-yl)ethan-1-amine hydrochloride (CAS 2624108-60-5)
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