4-(4-Chloro-2,8-dimethylquinolin-3-yl)butan-2-one CAS 309721-18-4
| CAS No. | 309721-18-4 |
| Molecular Formula | C15H16ClNO |
| Molecular Weight | 261.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(4-Chloro-2,8-dimethylquinolin-3-yl)butan-2-one (CAS 309721-18-4) is a high-purity analytical reference standard with the molecular formula C15H16ClNO and a molecular weight of 261.75 g/mol.
The molecular framework of 4-(4-Chloro-2,8-dimethylquinolin-3-yl)butan-2-one (C15H16ClNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H16ClNO |
| Molecular Weight | 261.75 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 4-(4-Chloro-2,6-dimethyl-3-quinolinyl)-2-butanone (CAS 332150-25-1)
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- tert-Butyl 6-chloro-3,5-dioxohexanoate (CAS 276249-18-4)
- L-Arginine L-aspartate (CAS 7675-83-4)
- (2-(3-Chloro-4-methoxyphenyl)cyclopropyl)methanamine (CAS 1483797-67-6)
- 2-(Methylsulfanyl)-4-(naphthalen-2-yloxy)thieno[2,3-d]pyrimidine (CAS 383147-01-1)
- 6-Chloro-4-fluoropyridine-3-carbaldehyde (CAS 1060809-20-2)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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