4,6-Bis(4-methoxyphenyl)-2-(methylthio)nicotinonitrile CAS 312757-89-4

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4,6-Bis(4-methoxyphenyl)-2-(methylthio)nicotinonitrile.

CATO supplies 4,6-Bis(4-methoxyphenyl)-2-(methylthio)nicotinonitrile (CAS 312757-89-4), a certified reference material (molecular formula C21H18N2O2S, MW 362.44 g/mol) for analytical method development and quality control.

Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, 4,6-Bis(4-methoxyphenyl)-2-(methylthio)nicotinonitrile is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 362.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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