Ethyl 4-amino-3-(2-fluorophenyl)-2-thioxo-2,3-dihydrothiazole-5-carboxylate CAS 312922-19-3
| CAS No. | 312922-19-3 |
| Molecular Formula | C12H11FN2O2S2 |
| Molecular Weight | 298.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethyl 4-amino-3-(2-fluorophenyl)-2-thioxo-2,3-dihydrothiazole-5-carboxylate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ethyl 4-amino-3-(2-fluorophenyl)-2-thioxo-2,3-dihydrothiazole-5-carboxylate (CAS 312922-19-3) is a high-purity analytical reference standard with the molecular formula C12H11FN2O2S2 and a molecular weight of 298.36 g/mol.
The molecular framework of Ethyl 4-amino-3-(2-fluorophenyl)-2-thioxo-2,3-dihydrothiazole-5-carboxylate (C12H11FN2O2S2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11FN2O2S2 |
| Molecular Weight | 298.36 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
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- Methyl 5-chloro-2-{[(E)-4,4,4-trifluoro-1-methyl-3-oxo-1-butenyl]amino}benzenecarboxylate (CAS 1210908-67-0)
- Tert-butyl 3-(3-aminophenyl)pyrrolidine-1-carboxylate (CAS 885270-24-6)
- 3-Chloro-2-phenoxyaniline (CAS 3169-75-3)
- Ethyl 2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-2,2-difluoroacetate (CAS 478043-86-6)
- 4-(Chloromethyl)-2,6-dimethylpyridine (CAS 120739-87-9)
- 6-(tert-Butyl)-2,3-difluoropyridine (CAS 1260667-28-4)
- Semaglutide impurity 73 (CAS CATO-C4X-222673)
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