2-(4-Fluorobenzyl)isoindoline-1,3-dione CAS 318-49-0
| CAS No. | 318-49-0 |
| Molecular Formula | C15H10FNO2 |
| Molecular Weight | 255.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(4-Fluorobenzyl)isoindoline-1,3-dione.
2-(4-Fluorobenzyl)isoindoline-1,3-dione (CAS 318-49-0), molecular formula C15H10FNO2 and molecular weight 255.24 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-(4-Fluorobenzyl)isoindoline-1,3-dione (C15H10FNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 255.24 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H10FNO2 |
| Molecular Weight | 255.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorobenzyl Standards
- 1-(3-Fluorobenzyl)indoline-2,3-dione (CAS 689757-49-1)
- 1-(4-Fluorobenzyl)-1h-indole-2,3-dione (CAS 313245-18-0)
- 1-(2-fluorobenzyl)-1H-indole-2,3-dione 346640-52-6 C15H10FNO2 HTS028128 (CAS 346640-52-6)
- 4-(4-Fluorobenzyl)thiomorpholine-3,5-dione 1-oxide (CAS 344264-10-4)
- (1-(3-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)methanamine (CAS 105969-02-6)
- (1-(4-Fluorobenzyl)-1H-indol-3-yl)methanol (CAS 195253-43-1)
- 5-(((4-Fluorobenzyl)thio)methyl)-1,3,4-thiadiazol-2-amine (CAS 292064-75-6)
- 5-((4-Fluorobenzyl)thio)-N-methyl-1,3,4-thiadiazol-2-amine (CAS 931046-37-6)
Recommended Standards
- 2-(4-(4-Fluorobenzoyl)phenoxy)acetonitrile (CAS 849527-69-1)
- 2-(4-Fluorophenyl)-1H-indole-3-carboxylic acid (CAS 773870-18-1)
- 2-(3,5-Dimethyl-1h-pyrazol-1-yl)-5-(trifluoromethyl)aniline (CAS 60418-61-3)
- 2-(4-Fluorophenyl)-1H-indole-4-carboxylic acid (CAS 917614-77-8)
- 5-(6-((2-Fluorobenzyl)thio)pyridazin-3-yl)-2,4-dimethylthiazole (CAS 894006-46-3)
- 2-Methyl-4-propoxybenzenethiol (CAS 1378809-61-0)
- 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-sulfonyl chloride (CAS 956389-93-8)
- 4-Methyl-3-(pyridin-2-yl)-1h-pyrazol-5-amine (CAS 1312617-00-7)
- (1,2,3,4-Tetrahydroisoquinolin-6-yl)methanol hydrochloride (CAS 2152637-00-6)
- (R)-4-(Methylthio)-2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)butanoic acid (CAS 162149-69-1)
- 1-(2-Amino-4-chlorophenyl)-2-methylpropan-1-one (CAS 151029-79-7)
- 3-(2-Chlorophenyl)-N-(6-ethoxybenzo[d]thiazol-2-yl)-5-methylisoxazole-4-carboxamide (CAS 545430-77-1)
- 1-([1,1'-Biphenyl]-4-ylamino)-4-aminoanthracene-9,10-dione (CAS 88653-18-3)
- Fibrinogen-Binding Peptide (CAS 137235-80-4)
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