1-Methyl-5-((2-methylbenzyl)sulfonyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile CAS 318284-65-0
| CAS No. | 318284-65-0 |
| Molecular Formula | C14H12F3N3O2S |
| Molecular Weight | 343.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Methyl-5-((2-methylbenzyl)sulfonyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile.
CATO supplies 1-Methyl-5-((2-methylbenzyl)sulfonyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile (CAS 318284-65-0), a certified reference material (molecular formula C14H12F3N3O2S, MW 343.32 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, 1-Methyl-5-((2-methylbenzyl)sulfonyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 343.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Methyl-5-((2-methylbenzyl)sulfonyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H12F3N3O2S |
| Molecular Weight | 343.32 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Methyl Standards
- 4-Methyl-1-((2-methylbenzyl)thio)thieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one (CAS 1189984-73-3)
- 2-(Methyl(4-methylbenzyl)amino)-2-oxoethyl 2-(methylthio)nicotinate (CAS 878606-14-5)
- 3-Methyl-7-(3-methylbenzyl)-8-(propylthio)-3,7-dihydro-1H-purine-2,6-dione (CAS 303973-40-2)
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- 1-(2-((3-Methylbenzyl)thio)-4,5-dihydro-1H-imidazol-1-yl)-2-phenoxyethan-1-one (CAS 851803-55-9)
- N'-(4-((4-Methylbenzyl)oxy)benzylidene)pyrazine-2-carbohydrazide (CAS 765298-52-0)
- 1,4-Bis(((4-methylbenzyl)oxy)methyl)benzene (CAS 136861-46-6)
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Recommended Standards
- (2S,4S)-1-(tert-Butoxycarbonyl)-4-(2,5-difluoro-phenoxy)-2-pyrrolidinecarboxylic acid (CAS 869682-02-0)
- 2,2,2-Trifluoro-1-phenyl-ethanone O-[(4-Methylphenyl)sulfonyl]oxime (CAS 40618-87-9)
- (2S,4S)-1-(tert-butoxycarbonyl)-4-(3,4-difluorophenoxy)pyrrolidine-2-carboxylic acid (CAS 1354486-27-3)
- 4-[(1E)-{[3-(trifluoromethyl)phenyl]imino}methyl]phenyl methanesulfonate (CAS 331460-67-4)
- (S)-1-Acetyl-pyrrolidine-2-carbaldehyde (CAS 1245939-87-0)
- tert-Butyl cis-3-fluoro-4-hydroxypiperidine-1-carboxylate (CAS 955028-88-3)
- 2-Chloro-N-(3-chloro-5-methoxy-2-methylphenyl)propanamide (CAS 1365962-98-6)
- 2-((5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)thio)acetic acid (CAS 40277-59-6)
- (1s)-1-(4,4-Dimethylcyclohexyl)ethan-1-ol (CAS 1423040-70-3)
- Entrectinib (CAS 1108743-60-7)
- rac Styrene Glycol-d (CAS 871217-81-1)
- 7-Bromo-6-chloro-5,8-difluoroquinazolin-4(3H)-one (CAS 2387928-71-2)
- Potassium trifluoro(3-methoxyphenyl)borate (CAS 438553-44-7)
- Peptide Impurity 34 (CAS 21282-09-7)
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