7-(Trifluoromethyl)quinolin-5-amine CAS 321-71-1
| CAS No. | 321-71-1 |
| Molecular Formula | C10H7F3N2 |
| Molecular Weight | 212.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-(Trifluoromethyl)quinolin-5-amine.
7-(Trifluoromethyl)quinolin-5-amine (CAS 321-71-1) is a high-purity analytical reference standard with the molecular formula C10H7F3N2 and a molecular weight of 212.17 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, 7-(Trifluoromethyl)quinolin-5-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 212.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 7-(Trifluoromethyl)quinolin-5-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7F3N2 |
| Molecular Weight | 212.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Trifluoromethyl Standards
- 8-(Trifluoromethyl)quinolin-6-amine (CAS 1080640-91-0)
- 6-(Trifluoromethyl)quinolin-3-amine (CAS 1082750-49-9)
- 8-(Trifluoromethyl)quinolin-2-amine (CAS 1092304-80-7)
- 7-(Trifluoromethyl)quinolin-2-amine (CAS 113508-12-6)
- 2-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]acetic acid (CAS 1154762-97-6)
- 6-(Trifluoromethyl)naphthalen-2-ol (CAS 116511-74-1)
- 7-(Trifluoromethyl)isoquinolin-1-amine (CAS 1196147-73-5)
- 6-(Trifluoromethyl)isoquinolin-1-amine (CAS 1196157-31-9)
Recommended Standards
- 7-(trifluoromethyl)quinolin-4-amine (CAS 243666-11-7)
- 7-(Trifluoromethyl)quinolin-8-amine (CAS 313-16-6)
- 7-(Trifluoromethyl)naphthalen-1-ol (CAS 33533-46-9)
- 8-(Trifluoromethyl)naphthalen-1-ol (CAS 33533-47-0)
- N-(1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide (CAS 121058-82-0)
- 3-Benzyloxyphenylacetonitrile (CAS 20967-96-8)
- 3-(Cbz-amino)propanenitrile (CAS 18877-96-8)
- N,N'-(Phenazine-2,3-diyl)dibenzamide (CAS 108112-50-1)
- (S)-1-(pyridin-3-yl)but-3-en-1-amine (CAS 314280-30-3)
- Ibuprofen EP Impurity A (CAS 66622-47-7)
- Oseltamivir impurity 202 (CAS CATO-C4X-1720202)
- 1,2-Dichloro-3-[2-chloro-1-(chloromethyl)ethoxy]-propane (CAS 59440-90-3)
- 2-(3-Hydroxypiperidin-1-yl)-1-phenylethan-1-one (CAS 1248914-71-7)
- Tau Peptide (295-309) trifluoroacetate salt (CAS 330456-46-7)
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