6-Fluoro-4H-benzo[d][1,3]dioxine-8-carboxylic acid CAS 321309-28-8
| CAS No. | 321309-28-8 |
| Molecular Formula | C9H7FO4 |
| Molecular Weight | 198.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
6-Fluoro-4H-benzo[d][1,3]dioxine-8-carboxylic acid (CAS 321309-28-8) is a high-purity analytical reference standard with the molecular formula C9H7FO4 and a molecular weight of 198.15 g/mol.
The molecular framework of 6-Fluoro-4H-benzo[d][1,3]dioxine-8-carboxylic acid (C9H7FO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7FO4 |
| Molecular Weight | 198.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
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Recommended Standards
- 5-Fluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid (CAS 524005-41-2)
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- 4-Fluoro-N-methyl-3-nitrobenzamide (CAS 475216-25-2)
- 2-Fluoro-N-methyl-4-nitrobenzamide (CAS 915087-24-0)
- 6-(2-Oxopropyl)-3,4-dihydroquinolin-2(1H)-one (CAS 119899-34-2)
- 4-(Azetidin-1-yl)-3-fluoropiperidine dihydrochloride (CAS 1803588-38-6)
- Ethyl 6-bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate (CAS 161468-52-6)
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- 1-Chloro-4-methylphthalazine (CAS 19064-68-7)
- (S)-tert-Butyl 3-((6-(cyclopropylamino)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylate (CAS 1353994-21-4)
- N-(2-(4-(hydroxymethyl)piperidin-1-yl)benzyl)thiophene-2-sulfonamide (CAS 860650-30-2)
- 2,5-Dibromo-4-nitroaniline (CAS 25462-68-4)
- Crustacean Cardioactive Peptide (CAS 107090-96-0)
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