(2E)-2-{[(4-chlorophenyl)amino]methylidene}-7-fluoro-3-phenyl-2,3-dihydro-1H-inden-1-one CAS 321430-66-4
| CAS No. | 321430-66-4 |
| Molecular Formula | C22H15ClFNO |
| Molecular Weight | 363.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (2E)-2-{[(4-chlorophenyl)amino]methylidene}-7-fluoro-3-phenyl-2,3-dihydro-1H-inden-1-one.
(2E)-2-{[(4-chlorophenyl)amino]methylidene}-7-fluoro-3-phenyl-2,3-dihydro-1H-inden-1-one (CAS 321430-66-4), molecular formula C22H15ClFNO and molecular weight 363.81 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, (2E)-2-{[(4-chlorophenyl)amino]methylidene}-7-fluoro-3-phenyl-2,3-dihydro-1H-inden-1-one (C22H15ClFNO) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 363.81 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2E)-2-{[(4-chlorophenyl)amino]methylidene}-7-fluoro-3-phenyl-2,3-dihydro-1H-inden-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H15ClFNO |
| Molecular Weight | 363.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 5-Chloro-N-(1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)cyclohexyl)-2-fluorobenzamide (CAS 1396799-48-6)
- Flamprop-M-isopropyl Solution (CAS 57973-67-8)
- 2-(4-Chlorothiophen-2-yl)cyclopropan-1-amine (CAS 1500167-83-8)
- 4-(N-Methylsulfamoyl)phenylboronic Acid (CAS 226396-31-2)
- 1-Chloro-3-ethylbenzene (CAS 620-16-6)
- 7H-Pyrrolo[2,3-c]pyridazine (CAS 16767-40-1)
- 2-Amino-9-((cis-2-(hydroxymethyl)cyclohexyl)methyl)-3H-purin-6(9H)-one (CAS 120330-37-2)
- 2-{4-[2-nitro-4-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl 3-(trifluoromethyl)benzoate (CAS 338748-62-2)
- tert-Butyl 2-(pyridin-3-ylamino)acetate (CAS 710939-70-1)
- 6-bromo-2,7-dimethyl-3,4-dihydro-2H-1,4-benzoxazine (CAS 1376281-76-3)
- Tedizolid Impurity 55 (CAS 919081-42-8)
- Semaglutide Impurity 10 (CAS CATO-C4X-222610)
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