5-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione CAS 321432-06-8
| CAS No. | 321432-06-8 |
| Molecular Formula | C14H13ClF3N5O2 |
| Molecular Weight | 375.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 321432-06-8) is a high-purity analytical reference standard with the molecular formula C14H13ClF3N5O2 and a molecular weight of 375.73 g/mol.
The molecular framework of 5-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione (C14H13ClF3N5O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H13ClF3N5O2 |
| Molecular Weight | 375.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related chloro Standards
- 3-Chloro-6'-phenoxy-5-(trifluoromethyl)-[2,3'-bipyridine]-5'-carbonitrile (CAS 339011-81-3)
- 5-[(1E)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}ethyl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 321432-20-6)
- 4-(2-(2-Chloro-4-nitrophenoxy)ethoxy)benzene-1-sulfonyl fluoride (CAS 21278-61-5)
- 4-(2-(2-Chloro-5-nitrophenoxy)ethoxy)benzene-1-sulfonyl fluoride (CAS 31185-43-0)
- Ethyl 2-((8-chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)thio)-2,2-difluoroacetate (CAS 1823182-39-3)
- (1Z)-1-{3-chloro-4-[(4-fluorophenyl)methoxy]phenyl}-N-(2,4-difluorophenyl)methanimine (CAS 297150-45-9)
- 2-(4-Chloro-3-nitrophenyl)-1H-imidazo[4,5-b]phenazine (CAS 303059-17-8)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 1823183-23-8)
Recommended Standards
- Haloxyfop-Methyl (CAS 69806-40-2)
- 5-(Naphthalen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride (CAS 865424-03-9)
- Haloxyfop-R-Methyl (CAS 72619-32-0)
- 5-(Naphthalen-1-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride (CAS 865424-05-1)
- N-(6-Chloropyrimidin-4-yl)cyclopropanecarboxamide (CAS 1072710-99-6)
- 4H-Benzo[d][1,2,3]triazole-5-carboxylic acid (CAS 1288339-47-8)
- 4-(Methylsulfonyl)-1H-pyrazol-5-amine hydrochloride (CAS 106232-39-7)
- FK 888 (CAS 138449-07-7)
- 3-{2-methylimidazo[1,2-a]pyridin-3-yl}piperazin-2-one dihydrochloride (CAS 1803566-49-5)
- 2-[(E)-2-(2,4-Dichlorophenyl)ethenyl]-1H-1,3-benzodiazole (CAS 206982-88-9)
- 6-(Phenylsulfonyl)-1-oxa-6-azaspiro[2.5]Octane (CAS 861208-92-6)
- 3-[(4-Chlorophenyl)sulfanyl]-1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione (CAS 32809-05-5)
- Ethyl 2-(1-Boc-3-pyrrolidyl)acetate (CAS 664364-29-8)
- Peptide T (CAS 106362-32-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com