N-(3,4-Difluorophenyl)-2,4-diphenylpyrimidine-5-carboxamide CAS 321433-26-5
| CAS No. | 321433-26-5 |
| Molecular Formula | C23H15F2N3O |
| Molecular Weight | 387.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 387.38 g/mol gives N-(3,4-Difluorophenyl)-2,4-diphenylpyrimidine-5-carboxamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N-(3,4-Difluorophenyl)-2,4-diphenylpyrimidine-5-carboxamide (CAS 321433-26-5), molecular formula C23H15F2N3O and molecular weight 387.38 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(3,4-Difluorophenyl)-2,4-diphenylpyrimidine-5-carboxamide (C23H15F2N3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(3,4-Difluorophenyl)-2,4-diphenylpyrimidine-5-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H15F2N3O |
| Molecular Weight | 387.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related N Standards
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Recommended Standards
- Allyl 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranoside (CAS 28738-44-5)
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- 4-Hydroxy-6-phenyl-2-({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)pyrimidine-5-carbonitrile (CAS 303985-06-0)
- Posaconazole Impurity 135 (CAS CATO-C4X-1208135)
- 1-(Piperazin-1-yl)-2-(o-tolyloxy)propan-1-one (CAS 143999-86-4)
- 3,7-Dimethyldibenzo[b,d]furan (CAS 41738-54-9)
- 2-Ethoxy-6-fluoro-4-methylphenylboronic acid (CAS 2121513-45-7)
- 1-Bromo-2-(difluoromethyl)-3-methylbenzene (CAS 1261642-37-8)
- 2-(5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbutanoic acid (CAS 1506407-35-7)
- 3-(5-Bromobenzofuran-2-yl)-3-oxopropanenitrile (CAS 1135283-25-8)
- Methyl 3-(2-nitrophenyl)-1H-pyrazole-5-carboxylate (CAS 57446-04-5)
- 2-Isonicotinoyl-N-methylhydrazinecarbothioamide (CAS 4406-96-6)
- tert-Butyl 4-((3-methylpyrazin-2-yl)amino)piperidine-1-carboxylate (CAS 1289384-62-8)
- Liraglutide Impurity 20 TFA Salt (CAS CATO-C4X-199220)
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